Marine collagen scaffolds in tissue engineering. (April 2022)

• Record Type: Journal Article
• Authors: Liu, Shaoqiong; Lau, Chau-Sang; Liang, Kun; Wen, Feng; Teoh, Swee Hin
• Is Part Of: Current opinion in biotechnology. Volume 74(2022)
• Page Start: 92
• Page End: 103
• Publication Date: 2022-04
• Subjects: Biotechnology -- Periodicals; 660.6
• DOI: 10.1016/j.copbio.2021.10.011
• Languages: English
• ISSNs: 0958-1669

Abstract

Graphical abstract: Highlights: Marine collagen is gaining prominence in tissue engineering as a sustainable biomaterial and a safe alternative to mammalian collagen. Marine collagen scaffolds can be fabricated by freeze drying, hydrogelation, electrospinning, 3D bioprinting and decellularization. Marine collagen scaffolds have been explored for various tissue engineering applications including skin, bone and cartilage regeneration. The use of marine collagen in tissue engineering is still an emerging area and holds tremendous promise. Abstract : Collagen is the primary component of the extracellular matrix in humans. Traditionally commercial collagen is confined to bovine and porcine sources which have concerns of pathogenic transfer. Marine wastage accounts up to 85% by weight in the fishing industry. Extraction of collagen from these wastes for economic value and environmental sustainability is clear. Marine collagens have several advantages such as excellent biocompatibility, lower zoonotic risks, less immunological risk for patients allergic to mammalian products, and less religious restrictions. However, the properties of marine collagen-based constructs are highly dependent on the methods of fabrication. This article reviews advances in the design and fabrication of marine collagen-based constructs for medical applications. The potential applications of marine collagen in the regeneration of skin, bone and cartilage were also highlighted.