Primary cilia and their effects on immune cell functions and metabolism: a model. Issue 5 (May 2022)

• Record Type: Journal Article
• Authors: Picon-Galindo, Ernesto; Latz, Eicke; Wachten, Dagmar
• Is Part Of: Trends in immunology. Volume 43:Issue 5(2022)
• Page Start: 366
• Page End: 378
• Publication Date: 2022-05
• Subjects: Immunology -- Periodicals; 571.96
• DOI: 10.1016/j.it.2022.03.001
• Languages: English
• ISSNs: 1471-4906

Abstract

Abstract : Primary cilia are hair-like protrusions of the plasma membrane that function as cellular antennae and are present on most cells in the human body. Primary cilia dysfunction leads to severe diseases, commonly termed 'ciliopathies'. A significant symptom of certain ciliopathies is obesity, and current research aims to identify contributing mechanisms of obesity development in these patients. Western lifestyle-associated factors can trigger chronic inflammation, or metaflammation, which can also attribute to obesity-associated metabolic disorders. However, obese individuals can also be 'metabolically healthy', as discussed for a subset of patients with obesity and ciliopathy. Here, we propose that primary cilia signaling might modulate specific immune cell phenotypes, behaviors, and functions, which might impact inflammatory responses in the context of ciliopathies and beyond. Highlights: A Western lifestyle triggers a subclinical immune response, also called metaflammation in humans and mice. Metaflammation is now thought to underlie the development of certain noncommunicable diseases associated with obesity. One of the major symptoms of the Bardet–Biedl Syndrome (BBS) ciliopathy in humans and mice is obesity; however, depending on the BBS mutation and age, the severity of metabolic syndrome varies. Primary cilia evoke cell-autonomous (in cytotoxic CD8 + T cells) and noncell-autonomous responses (in B lymphocytes and macrophages) that can control certain immune cell functions in humans and mice. Primary cilia dysfunction leading to ciliopathies can evoke tissue-specific responses in immune cells in humans and mice.