Hierarchically multifunctional bioactive nanoglass for integrated tumor/infection therapy and impaired wound repair. (March 2022)

• Record Type: Journal Article
• Authors: Chen, Mi; Winston, Dagogo Dorothy; Wang, Min; Niu, Wen; Cheng, Wei; Guo, Yi; Wang, Yidan; Luo, Meng; Xie, Chenxi; Leng, Tongtong; Qu, Xiaoyan; Lei, Bo
• Is Part Of: Materials today. Volume 53(2022)
• Page Start: 27
• Page End: 40
• Publication Date: 2022-03
• Subjects: Bioactive materials -- Bioactive glass -- Multifunctional -- Tissue engineering -- Skin repair; Materials science -- Periodicals; Metallurgy -- Periodicals; Metal-work -- Periodicals; Biomedical and Dental Materials -- Periodicals; Manufactured Materials -- Periodicals; Metals -- Periodicals; 620.11
• DOI: 10.1016/j.mattod.2022.01.019
• Languages: English
• ISSNs: 1369-7021

Abstract

Graphical abstract: Abstract: The complex wound repair induced by tumor surgery and infection is still the clinical challenge due to the subsequent tumor recurrence and serious inflammation. Herein, we develop a bioactive Si-Ca-Sr glass-based therapy-regeneration-enabled nanohybrids (BSr@PPE) with hierarchical versatility for overcoming the challenges of tumor and infection-impaired wound repair. BSr@PPE showed a representative concentration-dependent photothermal effect, strong free radical scavenging and antibacterial ability, as well as good UV-shielding properties and high biocompatibility. BSr@PPE could efficiently kill tumor cells through the photothermal effect, show the robust antibacterial activity against normal and multi-drug resistant bacteria and enhance the fibroblasts migration in vitro . In vivo animal experiments suggested that BSr@PPE could effectively promote epithelial reconstruction, collagen deposition and angiogenesis in normal wounds, reduce inflammation and enhance repair in multi-drug bacterial infected wounds, accelerate the tumor-impaired wound through inhibit the tumor cells. This work may provide a new strategy and multifunctional bioactive material for treating the tissue repair and regeneration under the multi-pathological environments.