"Depart from evil, and do good": Turning Axl from uncontrolled tumorigenic gene to biomarker for early detection of pancreatic cancer. (May 2022)

• Record Type: Journal Article
• Authors: Comandatore, Annalisa; Balsano, Rita; Immordino, Benoit; Arguedas, Davinia; Capula, Mjriam; Baglio, Serena R.; Garajovà, Ingrid; Malapelle, Umberto; Morelli, Luca; Giovannetti, Elisa
• Is Part Of: Critical reviews in oncology/hematology. Volume 173(2022)
• Publication Date: 2022-05
• Subjects: Pancreatic cancer -- Liquid biopsies -- AXL -- Diagnosis; Oncology -- Periodicals; Hematology -- Periodicals; 616.994
• DOI: 10.1016/j.critrevonc.2022.103659
• Languages: English
• ISSNs: 1040-8428

Abstract

Abstract: Attempts to achieve early diagnosis are crucial to improve the outcome of patients with pancreatic ductal adenocarcinoma (PDAC). Here we present a critical evaluation of a recent study unraveling the potential of circulating AXL as a novel blood marker for early detection of PDAC and differential diagnosis from chronic pancreatitis (CP).