Osteonecrosis of the jaw induced by bisphosphonates therapy in bone metastases patient: Case report and literature review. (May 2022)

• Record Type: Journal Article
• Authors: Hao, Lei; Tian, Zhuoli; Li, Shanli; Yan, Kemin; Xue, Yan
• Is Part Of: Oral oncology. Volume 128(2022)
• Publication Date: 2022-05
• Subjects: Bisphosphonates -- MRONJ -- L-PRF -- Bone resection -- Treatment; Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2022.105852
• Languages: English
• ISSNs: 1368-8375

Abstract

Abstract: Medication-related osteonecrosis of the jaw (MRONJ) is an increasingly common bone-related adverse event in recent years. We reported 3 bone metastases of patients who developed MRONJ after receiving bisphosphonates therapy. All patients underwent surgical necrotic bone resection combined with leukocyte and platelet-rich fibrin concentrate (L-PRF) therapy. After 6 months of follow-up, no recurrence and adverse event has been observed. This report shows that treatment with necrotic bone resection and L-PRF is an effective therapy and should be considered as an alternative treatment for the management of advanced cases of MRONJ.