Diabetes reversal: Update on current knowledge and proposal of prediction score parameters for diabetes remission. Issue 4 (April 2022)

• Record Type: Journal Article
• Authors: Singla, Rajiv; Gupta, Geetu; Dutta, Deep; Raizada, Nishant; Aggarwal, Sameer
• Is Part Of: Diabetes & metabolic syndrome. Volume 16:Issue 4(2022)
• Publication Date: 2022-04
• Subjects: Diabetes reversal -- Lifestyle modification -- Diet -- Low calorie diet -- Low carb diet -- Diabetes subtypes -- Diabetes remission prediction score parameters; Diabetes -- Periodicals; Metabolism -- Disorders -- Periodicals; Diabetes Mellitus -- Periodicals; Metabolic Diseases -- Periodicals; Diabète -- Périodiques; Métabolisme, Troubles du -- Périodiques; Endocrinologie -- Périodiques; Diabète -- Physiopathologie -- Périodiques; Diabetes; Metabolism -- Disorders; Electronic journals; Periodicals; 616.462
• DOI: 10.1016/j.dsx.2022.102452
• Languages: English
• ISSNs: 1871-4021

Abstract

Abstract: Background and aim: The field of diabetes reversal is continuously evolving. Strategies for implementing diabetes care towards diabetes reversal are still being worked out. We aim to analyse data from available literature to ascertain factors allowing patient centric dietary approach to achieve diabetes reversal in clinical practice. Methods: In this exploratory review, an update on current knowledge is presented to delineate factors driving diabetes remission in an individual based on major studies in the field. This knowledge is then applied to subtypes of type 2 diabetes to optimise dietary approach for reversal of diabetes. Results and conclusion: Shorter duration of diabetes, lesser number of medicines needed to achieve euglycemia and 15 kg weight loss are common factors favouring diabetes remission in all major studies. A patient centric approach to diabetes reversal taking into account the recently described diabetes subtypes is being proposed to improve the proportion of patients achieving remission. We also propose the parameters of a novel diabetes remission prediction score, based on patient motivation, interaction with the care-team, level of diabetes self-care and the intent of the care-team. Highlights: Translation of diabetes reversal research to clinical practice is needed to achieve paradigm change in diabetes care. Both very low calorie diets or from low carbohydrate diets are modalities of achieving diabetes remission. A patient-centric dietary approach to diabetes remission may enhance chances of achieving remission in an individual. Based on current knowledge, it is possible to define parameters of diabetes remission prediction score.