A mathematical model for treatment using chemo-immunotherapy. Issue 4 (April 2022)

• Record Type: Journal Article
• Authors: Nave, Ophir
• Is Part Of: Heliyon. Volume 8:Issue 4(2022)
• Publication Date: 2022-04
• Subjects: Cancer protocol -- Mathematical model -- Dosage -- Chemo-immunotherapy -- GBM; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2022.e09288
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: In this study, we investigated a mathematical model for chemoimmunotherapy (a combination of chemotherapy and immunotherapy) for brain cancer. In most cases, the standard protocol for cancer treatment is fixed in terms of treatment time intervals and dosages. We offer a wide range of non-fixed protocols, which essentially vary in terms of time intervals and dosages (i.e., personalised medicine). The functions that describe this treatment are explicit and analytical. Hence, the parameters of the function can be easily changed and a new protocol can be obtained. We compared different protocols and obtained an optimal solution. In addition, we applied the singular perturbed vector field (SPVF) method to determine the hierarchy of the system of equations, which enabled us to identify the equilibrium points of the mathematical model and investigate their stability. Abstract : Cancer protocol; Mathematical model; Dosage; Chemo-immunotherapy; GBM