Role of β2-microglobulin in postoperative cognitive decline. (March 2017)

• Record Type: Journal Article
• Authors: Załęska-Kocięcka, Marta; Jezierski, Paweł; Grabowski, Maciej; Kuśmierski, Krzysztof; Dąbrowski, Maciej; Piotrowska, Katarzyna; Banaszewski, Marek; Imiela, Jacek; Stępińska, Janina
• Is Part Of: Biomarkers in medicine. Volume 11:Number 3(2017)
• Page Start: 245
• Page End: 253
• Publication Date: 2017-03
• Subjects: β2-microglobulin -- aging -- anesthesia -- cognition -- kidney biomarkers -- postoperative cognitive decline -- surgery; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm-2016-0274
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: β2-microglobulin (β2M) was proved to affect hippocampal functions in mice.Materials & methods: Seventy-one patients undergoing aortic valve replacement were analyzed in prospective observational study. Kidney biomarkers and Mini Mental State Examinations (MMSEs) were performed before procedure, at discharge and after 6 months.Results: Patients with β2M increase over the median change (>0.42 mg/l) experienced a significant in-hospital drop in MMSE (p = 0.005). Patients with β2M increase over the median change also failed to improve a delayed-word-recall domain of the test (p = 0.826) while patients with a lower increase improved results in the domain (p = 0.004). After 6 months, MMSE improvement was associated with a significant decrease in β2M (p = 0.042).Conclusion: These are the first in man data demonstrating relation between changes in cognition and β2M. The phenomenon was reversible which indicates its therapeutic potential.