The association of plasma miR-155 and VCAM-1 levels with coronary collateral circulation. (February 2017)

• Record Type: Journal Article
• Authors: Wang, Junnan; Yan, Youyou; Song, Dandan; Liu, Lulu; Liu, Bin
• Is Part Of: Biomarkers in medicine. Volume 11:Number 2(2017)
• Page Start: 125
• Page End: 131
• Publication Date: 2017-02
• Subjects: biomarker -- coronary artery disease -- coronary collateral circulation -- ELISA -- inflammation -- miR-155 -- miRNA -- qRT-PCR -- Rentrop grade -- VCAM-1; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm-2016-0282
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: Inflammation plays an important role in development of coronary collateral circulation (CCC). The aim of this study is to determine whether the inflammation-related miRNA miR-155 and the inflammation marker VCAM-1 could be a biomarker for CCC.Patients & methods: We measured levels of plasma VCAM-1 and miR-155 in patients with CCC according to Rentrop grade by ELISA or real-time polymerase chain reaction, respectively (n = 112).Results: Plasma miR-155 was negatively correlated with VCAM-1 in the poor CCC group and with Rentrop grade in all patients with CCC. In addition, plasma VCAM-1 was significantly decreased in CAD patients with CCC.Conclusion: Plasma miR-155 might be a potent independent predictor of collateral formation.