Trends in effectiveness of inactivated influenza vaccine in children by age groups in seven seasons immediately before the COVID-19 era. Issue 22 (11th May 2022)
- Record Type:
- Journal Article
- Title:
- Trends in effectiveness of inactivated influenza vaccine in children by age groups in seven seasons immediately before the COVID-19 era. Issue 22 (11th May 2022)
- Main Title:
- Trends in effectiveness of inactivated influenza vaccine in children by age groups in seven seasons immediately before the COVID-19 era
- Authors:
- Shinjoh, Masayoshi
Furuichi, Munehiro
Kobayashi, Hisato
Yamaguchi, Yoshio
Maeda, Naonori
Yaginuma, Mizuki
Kobayashi, Ken
Nogayama, Taisuke
Chiga, Michiko
Oshima, Mio
Kuramochi, Yuu
Yamada, Go
Narabayashi, Atsushi
Ookawara, Ichiro
Nishida, Mitsuhiro
Tsunematsu, Kenichiro
Kamimaki, Isamu
Shimoyamada, Motoko
Yoshida, Makoto
Shibata, Akimichi
Nakata, Yuji
Taguchi, Nobuhiko
Mitamura, Keiko
Takahashi, Takao - Abstract:
- Highlights: Flu vaccine effectiveness for children was analyzed for 2013/14 to 2019/20. Recent inactivated flu vaccine is effective in children and infants for flu A. Vaccine effectiveness was highest among 1 to 2 year olds for flu A and flu B. Flu vaccine effectively prevents flu A hospital admission in children aged 1–12. Abstract: Background: We have reported the vaccine effectiveness of inactivated influenza vaccine in children aged 6 months to 15 years between the 2013/14 and 2018/19 seasons. Younger (6–11 months) and older (6–15 years old) children tended to have lower vaccine effectiveness. The purpose of this study is to investigate whether the recent vaccine can be recommended to all age groups. Methods: The overall adjusted vaccine effectiveness was assessed from the 2013/14 until the 2020/21 season using a test-negative case-control design based on rapid influenza diagnostic test results. Vaccine effectiveness was calculated by influenza type and by age group (6–11 months, 1–2, 3–5, 6–12, and 13–15 years old) with adjustments including influenza seasons. Results: A total of 29, 400 children (9347, 4435, and 15, 618 for influenza A and B, and test-negatives, respectively) were enrolled. The overall vaccine effectiveness against influenza A, A(H1N1)pdm09, and B was significant (44% [95% confidence interval (CI), 41–47], 63% [95 %CI, 51–72], and 37% [95 %CI, 32–42], respectively). The vaccine was significantly effective against influenza A and B, except amongHighlights: Flu vaccine effectiveness for children was analyzed for 2013/14 to 2019/20. Recent inactivated flu vaccine is effective in children and infants for flu A. Vaccine effectiveness was highest among 1 to 2 year olds for flu A and flu B. Flu vaccine effectively prevents flu A hospital admission in children aged 1–12. Abstract: Background: We have reported the vaccine effectiveness of inactivated influenza vaccine in children aged 6 months to 15 years between the 2013/14 and 2018/19 seasons. Younger (6–11 months) and older (6–15 years old) children tended to have lower vaccine effectiveness. The purpose of this study is to investigate whether the recent vaccine can be recommended to all age groups. Methods: The overall adjusted vaccine effectiveness was assessed from the 2013/14 until the 2020/21 season using a test-negative case-control design based on rapid influenza diagnostic test results. Vaccine effectiveness was calculated by influenza type and by age group (6–11 months, 1–2, 3–5, 6–12, and 13–15 years old) with adjustments including influenza seasons. Results: A total of 29, 400 children (9347, 4435, and 15, 618 for influenza A and B, and test-negatives, respectively) were enrolled. The overall vaccine effectiveness against influenza A, A(H1N1)pdm09, and B was significant (44% [95% confidence interval (CI), 41–47], 63% [95 %CI, 51–72], and 37% [95 %CI, 32–42], respectively). The vaccine was significantly effective against influenza A and B, except among children 6 to 11 months against influenza B. The age group with the highest vaccine effectiveness was 1 to 2 years old with both influenza A and B (60% [95 %CI, 55–65] and 52% [95 %CI, 41–61], respectively). Analysis for the 2020/21 season was not performed because no cases were reported. Conclusions: This is the first report showing influenza vaccine effectiveness by age group in children for several seasons, including immediately before the coronavirus disease (COVID-19) era. The fact that significant vaccine effectiveness was observed in nearly every age group and every season shows that the recent vaccine can still be recommended to children for the upcoming influenza seasons, during and after the COVID-19 era. … (more)
- Is Part Of:
- Vaccine. Volume 40:Issue 22(2022)
- Journal:
- Vaccine
- Issue:
- Volume 40:Issue 22(2022)
- Issue Display:
- Volume 40, Issue 22 (2022)
- Year:
- 2022
- Volume:
- 40
- Issue:
- 22
- Issue Sort Value:
- 2022-0040-0022-0000
- Page Start:
- 3018
- Page End:
- 3026
- Publication Date:
- 2022-05-11
- Subjects:
- Influenza -- Children -- Vaccine -- Vaccine effectiveness -- Test-negative design -- COVID-19 era
Vaccines -- Periodicals
615.372 - Journal URLs:
- http://www.sciencedirect.com/science/journal/0264410X ↗
http://www.clinicalkey.com/dura/browse/journalIssue/0264410X ↗
http://www.clinicalkey.com.au/dura/browse/journalIssue/0264410X ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.vaccine.2022.04.033 ↗
- Languages:
- English
- ISSNs:
- 0264-410X
- Deposit Type:
- Legaldeposit
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- Available online (eLD content is only available in our Reading Rooms) ↗
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- British Library DSC - 9138.628000
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