The duplexity of unconventional T cells in cancer. (May 2022)

• Record Type: Journal Article
• Authors: Lawrence, Mark; Wiesheu, Robert; Coffelt, Seth B.
• Is Part Of: International journal of biochemistry & cell biology. Volume 146(2022)
• Publication Date: 2022-05
• Subjects: Unconventional T cells -- Cancer -- Mouse models -- Gamma delta T cells -- MAIT cells -- NKT cells; Biochemistry -- Periodicals; Cytology -- Periodicals; Biochemistry -- Periodicals; Cell Biology -- Periodicals; Biochimie -- Périodiques; Cytologie -- Périodiques; Biochimie; Cytologie; Biochemistry; Cytology; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); Periodicals; 572.05
• DOI: 10.1016/j.biocel.2022.106213
• Languages: English
• ISSNs: 1357-2725

Abstract

Abstract: Unconventional T cells and their involvement in cancer are understudied in comparison to conventional T cells, but recent findings indicate that these cells play important roles in both cancer progression and inhibition. Here, we briefly review the dichotomous role of three unconventional T cell lineages: γδ T cells, MAIT cells and NKT cells. Studies using mouse models of cancer show how this unconventional trilogy interacts with cancer epithelial cells and other immune cell populations during tumour evolution. These reports highlight various potential avenues for therapeutic intervention that may be exploited for cancer immunotherapy.