The association between Memorial Sloan Kettering Frailty Index with 30-day survival among patients aged ≥ 75 with cancer and COVID-19. Issue 4 (May 2022)

• Record Type: Journal Article
• Authors: Kim, Soo Jung; Fessele, Kristen L.; Tin, Amy L.; Malling, Charlotte; Litchfield, Hayley; Korc-Grodzicki, Beatriz; Shahrokni, Armin
• Is Part Of: Journal of geriatric oncology. Volume 13:Issue 4(2022)
• Page Start: 416
• Page End: 419
• Publication Date: 2022-05
• Subjects: Aging -- Frailty -- Cancer -- COVID-19; Geriatric oncology -- Periodicals; Neoplasms -- Periodicals; Aged -- Periodicals; Geriatric oncology; Electronic journals; Periodicals; 618.976994005
• DOI: 10.1016/j.jgo.2021.12.014
• Languages: English
• ISSNs: 1879-4068

Abstract

Abstract: Background: Advanced age and multiple comorbidities have been established as a risk factor for more severe disease and increased mortality among patients with COVID-19, yet the impact of frailty in patients with cancer 75 years and older who are admitted, remains unclear. Methods: To better understand the clinical presentation and course of illness for this population, we conducted a chart review of patients with cancer age 75 and older who were admitted to a comprehensive cancer center within 72 h of a confirmed COVID-19 diagnosis over a three-month period (March 1, 2020-May 31, 2020). Frequency and proportion of characteristics were reported. We additionally assessed the association between frailty and 30-day mortality using univariable logistic regression. Results: Our cohort consisted of 70 patients. We found evidence that increased frailty based on MSK-FI was associated with increased risk of 30-day mortality (OR 1.37, 95% CI 1.00, 1.87; p -value = 0.051), though this did not meet conventional levels of significance. Conclusion: Our analysis showed evidence of some association between degree of frailty and 30-day survival among older patients with cancer aged ≥75 who were admitted with COVID-19 infection. This finding illustrates the importance of frailty screening in the care management of older patients with cancer and COVID-19.