Functional neuroanatomy of allocentric remote spatial memory in rodents. (May 2022)

• Record Type: Journal Article
• Authors: Zorzo, Candela; Arias, Jorge L.; Méndez, Marta
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 136(2022)
• Publication Date: 2022-05
• Subjects: α-CaMKII Ca2 + /calmodulin-dependent kinase II-α -- ACC anterior cingulate cortex -- AChE acetylcholinesterase -- AMPA α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid -- ANT anterior thalamic nuclei -- Ara-C cytosine arabinoside -- CCO cytochrome c oxidase -- cKO conditional knock-out -- CTCF CCCTC-binding factor -- DG dentate gyrus -- DLO dorso-lateral orbital cortex -- DNMT DNA methyltransferase -- EE environmental enrichment -- FrAs frontal association -- HC hippocampus -- HT heterozygous -- IEG immediate early genes -- IL infralimbic cortex -- ILN/LT intralaminar nuclei/ lateral thalamic nuclei -- Ins insular area -- KO knock-out -- L-VGCCs L-type voltage-gated calcium channels -- L2/3 Layers 2/3 -- L4 layer 4 -- lENT lateral entorhinal cortex -- M1 primary motor cortex -- M2 secondary motor cortex -- MAM methylazoxymethanol acetate -- mENT medial entorhinal cortex -- MO medial orbital -- mPFC medial prefrontal cortex -- MS/Vddb medial septum/vertical diagonal band of Broca -- mtDNA mitochondrial DNA -- MTT multiple trace theory -- MWM Morris water maze -- NeuN neuron-specific nuclear protein -- NMB nucleus basalis magnocellularis -- NMDA N-methyl-D-aspartate -- PAR parietal cortex -- PL prelimbic cortex -- PKMζ protein kinase M zeta -- PND postnatal day -- pPtA posterior parietal association cortex -- pRe perireuniens -- PRh perirhinal cortex -- RA retrograde amnesia -- RAM radial arm maze -- Re reuniens -- ReRh reuniens and rhomboid -- Rh rhomboid -- RSP retrosplenial cortex, S1, primary somatosensory cortex -- S2 secondary somatosensory cortex -- SCT standard consolidation theory -- STR striatum -- TGRA temporary graded retrograde amnesia -- V1 primary visual cortex -- V2M medial secondary visual cortex -- V2L lateral secondary visual cortex; Remote memory -- Retrieval -- Allocentric strategy -- Rodents -- System consolidation; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2022.104609
• Languages: English
• ISSNs: 0149-7634

Abstract

Abstract: Successful spatial cognition involves learning, consolidation, storage, and later retrieval of a spatial memory trace. The functional contributions of specific brain areas and their interactions during retrieval of past spatial events are unclear. This systematic review collects studies about allocentric remote spatial retrieval assessed at least two weeks post-acquisition in rodents. Results including non-invasive interventions, brain lesion and inactivation experiments, pharmacological treatments, chemical agent administration, and genetic manipulations revealed that there is a normal forgetting when time-periods are close to or exceed one month. Moreover, changes in the morphology and functionality of neocortical areas, hippocampus, and other subcortical structures, such as the thalamus, have been extensively observed as a result of spatial memory retrieval. In conclusion, apart from an increasingly neocortical recruitment in remote spatial retrieval, the hippocampus seems to participate in the retrieval of fine spatial details. These results help to better understand the timing of memory maintenance and normal forgetting, outlining the underlying brain areas implicated. Highlights: Decline of rodent spatial memory is observed at longer retentions than a month. Neocortex, and specially the prefrontal cortex, is critical to retrieve memories. Hippocampus will be always necessary to retrieve spatial information. Brain morphology and functionality can change due to retrieval of past events.