Baveno VI criteria as a prognostic factor for clinical complications in patients with compensated cirrhosis. Issue 5 (May 2022)

• Record Type: Journal Article
• Authors: Asesio, Nicolas; Pollo-Flores, Priscila; Caliez, Olivier; Munteanu, Mona; Ngo, An; Ngo, Yen; Poynard, Thierry; Thabut, Dominique; Rudler, Marika
• Is Part Of: Digestive and liver disease. Volume 54:Issue 5(2022)
• Page Start: 645
• Page End: 653
• Publication Date: 2022-05
• Subjects: Compensated advanced chronic liver disease -- Portal hypertension -- Hepatocellular carcinoma; PHT Portal hypertension -- HE Hepatic Encephalopathy -- VB Variceal Bleeding -- VNT Varices Needing Treatment -- cACLD compensated Advanced Chronic Liver Disease -- LSM Liver Stiffness Measurement -- HVPG Hepatic Venous Pressure Gradient -- HCC Hepatocellular Carcinoma -- TE Transient elastography -- AST Aspartate aminotransferase -- ALT Alanine aminotransferase -- CHC Chronic Hepatitis C -- CHB Chronic Hepatitis B -- NASH Non Alcoholic Steatohepatitis -- SVR sustained viral response -- INR International Normalized Ratio -- BMI Body Mass Index -- MELD Model for End-Stage Liver Disease -- CI Confidence Interval -- PSVD Porto-Sinusoidal Vascular Disease -- cccDNA covalently closed circular DNA -- MAFLD Metabolic Associated Fatty Liver Disease; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2021.09.004
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: Background: Combination of liver stiffness measurement and platelets count is a tool to safely rule out varices needing treatment (VNT) in patients with compensated advanced chronic liver disease (cACLD). Aims: to evaluate 4-year liver-related complications and survival in low-risk patients according to Baveno VI criteria. Methods: we conducted a monocentric retrospective analysis of prospectively collected data of all consecutive patients, with cirrhosis (LSM≥12.5 kPa) and without previous complication, evaluated between 2012 and 2015. Liver-related complications and survival were compared between 2 groups of patients: favourable (LSM< 20 kPa and platelet count>150.000/mm3) and unfavourable Baveno VI status patients (LSM ≥ 20 kPa or platelet count ≤150.000/mm3). Results: 455 patients with cACLD were analysed. Two hundred patients had favourable Baveno VI criteria, 3.6% with VNT. The 4-year probability of being free of acute decompensation was higher in low-risk patients (94.4 ± 1.8% vs. 85.7%±2.6%, p = 0.018). Unfavourable Baveno status was independently associated with acute decompensation. The probability of being free of HCC was significantly higher in low-risk patients (94.2 ± 1.8% vs. 87.6 ± 2.4%, p = 0.048). Liver-related mortality was not different between the 2 groups ( p = 0.56). Conclusion: The Baveno VI criteria could predict clinical outcome in cACLD.