Biosensing with Fluorescent Carbon Nanotubes. (1st March 2022)

• Record Type: Journal Article
• Authors: Ackermann, Julia; Metternich, Justus T.; Herbertz, Svenja; Kruss, Sebastian
• Is Part Of: Angewandte Chemie. Volume 134:Number 18(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-01
• Subjects: biosensors -- carbon nanotubes -- imaging -- molecular recognition -- near-infrared fluorescence; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202112372
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Biosensors are powerful tools for modern basic research and biomedical diagnostics. Their development requires substantial input from the chemical sciences. Sensors or probes with an optical readout, such as fluorescence, offer rapid, minimally invasive sensing of analytes with high spatial and temporal resolution. The near‐infrared (NIR) region is beneficial because of the reduced background and scattering of biological samples (tissue transparency window) in this range. In this context, single‐walled carbon nanotubes (SWCNTs) have emerged as versatile NIR fluorescent building blocks for biosensors. Here, we provide an overview of advances in SWCNT‐based NIR fluorescent molecular sensors. We focus on chemical design strategies for diverse analytes and summarize insights into the photophysics and molecular recognition. Furthermore, different application areas are discussed—from chemical imaging of cellular systems and diagnostics to in vivo applications and perspectives for the future. Abstract : Optical biosensors are important tools for basic research and non‐invasive diagnostics. Carbon nanotubes are versatile near‐infrared fluorescent and non‐bleaching materials that can be chemically functionalized to detect a broad variety of biomolecules. This Review highlights chemical design strategies and provides a comprehensive overview of the recent developments in this dynamic field.