Lung parenchymal calcifications in a child with cystic fibrosis. Issue 5 (31st March 2022)

• Record Type: Journal Article
• Authors: Lynch, Heidi; Qian, Frank; Wong, Matthew D.; Thomas, Rahul J.; Kapur, Nitin
• Is Part Of: Respirology case reports. Volume 10:Issue 5(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-31
• Subjects: cystic fibrosis -- lung calcifications; Respiratory organs -- Diseases -- Periodicals; 616.2005
• DOI: 10.1002/rcr2.941
• Languages: English
• ISSNs: 2051-3380

Abstract

Abstract: We describe a 6‐year‐old girl with homozygous p.Phe508del cystic fibrosis with severe multi‐lobar bronchiectasis and obstructive lung disease who was found to have prominent parenchymal calcifications in the right middle lobe on a computed tomography scan of the chest. Histopathology from the calcified area of lung biopsy showed fibrous tissue with chronic inflammation with CD3+ T‐lymphocytes and macrophages with no granulomas. Dystrophic calcification was seen within this necrotic debris. Abstract : This study reports the first case of extensive parenchymal lung calcification in a child with cystic fibrosis. The aetiology of lung calcification in this case is not attributable to metastatic lung calcification or tubercular mycobacterial infection.