A pH‐Responsive Nanoparticle Library with Precise pH Tunability by Co‐Polymerization with Non‐Ionizable Monomers. Issue 19 (10th March 2022)

• Record Type: Journal Article
• Authors: Zhao, Ruiyang; Fu, Chuanxun; Wang, Zenghui; Pan, Meijie; Ma, Bin; Yin, Qingqing; Chen, Binlong; Liu, Jianxiong; Xia, Heming; Wan, Fangjie; Wang, Letong; Zhang, Qiang; Wang, Yiguang
• Is Part Of: Angewandte Chemie international edition. Volume 61:Issue 19(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-10
• Subjects: Fluorescence Imaging -- Nanoparticles -- Non-Ionizable Monomers -- Polymerization -- pH Tunability; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202200152
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Precise monitoring of the subtle pH fluctuation during biological events remains a big challenge. Previously, we reported an ultra‐pH‐sensitive (UPS) nanoprobe library with a sharp pH response using co‐polymerization of two tertiary amine‐containing monomers with distinct p K a . Currently, we have generalized the UPS nanoparticle library with tunable pH transitions (pHt ) by copolymerization of a tertiary amine‐containing monomer with a series of non‐ionizable monomers. The pHt of nanoparticles is fine‐tuned by the non‐ionizable monomers with different hydrophobicity. Each non‐ionizable monomer presents a constant contribution to pH tunability regardless of tertiary amine‐containing monomers. Based on this strategy, we produced two libraries of nanoprobes with continuous pHt covering the entire physiological pH range (5.0–7.4) for fluorescent imaging of endosome maturation and cancers. This generalized strategy provides a powerful toolkit for biological studies and cancer theranostics. Abstract : A generalized strategy for the development of an ultra‐pH‐sensitive nanoparticle library with precisely tuned pH transitions (pHt =4.0–7.4) was proposed through co‐polymerization of a tertiary amine‐containing monomer with a series of non‐ionizable monomers. The nanoprobe library exhibits excellent barcode imaging of endosome maturation and precise cancer imaging.