Bioceramic Scaffolds with Antioxidative Functions for ROS Scavenging and Osteochondral Regeneration. Issue 12 (19th February 2022)

• Record Type: Journal Article
• Authors: Deng, Cuijun; Zhou, Quan; Zhang, Meng; Li, Tian; Chen, Haotian; Xu, Chang; Feng, Qishuai; Wang, Xin; Yin, Feng; Cheng, Yu; Wu, Chengtie
• Is Part Of: Advanced science. Volume 9:Issue 12(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-19
• Subjects: antioxidant defense -- arthritis therapy -- bioceramic scaffolds -- osteochondral regeneration -- ROS scavenging; Science -- Periodicals; 505
• DOI: 10.1002/advs.202105727
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Osteoarthritis (OA) is a degenerative disease that involves excess reactive oxygen species (ROS) and osteochondral defects. Although multiple approaches have been developed for osteochondral regeneration, how to balance the biochemical and physical microenvironment in OA remains a big challenge. In this study, a bioceramic scaffold by 3D printed akermanite (AKT) integrated with hair‐derived antioxidative nanoparticles (HNPs)/microparticles (HMPs) for ROS scavenging and osteochondral regeneration has been developed. The prepared bioscaffold with multi‐mimetic enzyme effects, which can scavenge a broad spectrum of free radicals in OA, can protect chondrocytes under the ROS microenvironment. Importantly, the bioscaffold can distinctly stimulate the proliferation and maturation of chondrocytes due to the stimulation of the glucose transporter pathway (GLUT) via HNPs/HMPs. Furthermore, it significantly accelerated osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). In vivo results showed that the bioscaffold can effectively enhance the osteochondral regeneration compared to the unmodified scaffold. The work shows that integration of antioxidant and mechanical properties via the bioscaffold is a promising strategy for osteochondral regeneration in OA treatment. Abstract : A bioceramic scaffold by 3D printed akermanite (AKT) integrated with hair‐derived antioxidative nanoparticles (HNPs)/microparticles (HMPs) for ROS scavenging and osteochondral regeneration has been developed. The bioscaffold with multi‐mimetic enzyme effects can stimulate osteogenic differentiation of rBMSCs and promoted chondrocytes maturation, which further protects chondrocytes from OA.