An effortless approach to synthesize two structurally diverse nano copper(II) materials and assessment of their apoptosis‐inducing ability on lung cancer cell line. (7th March 2022)

• Record Type: Journal Article
• Authors: Biswas, Sneha; Karim, Suhana; Zangrando, Ennio; Chandra, Arpita
• Is Part Of: Applied organometallic chemistry. Volume 36:Number 5(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-07
• Subjects: apoptosis -- copper Schiff base -- lung cancer -- nanomaterial; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.6659
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract: Two architecturally dissimilar coordination complexes, namely, C1 = [CuL 1 (NO2 )]2 and C2 = [CuL 2 (NO3 )] (L 1 = (4‐bromo‐2‐[(2‐isobutylaminoethylimino)methyl]phenolate and L 2 = (4‐bromo‐2‐[(2‐propylaminoethylimino)methyl]phenolate) have been synthesized from two different organic ligand backbones. The synthesized complexes have been identified using some common techniques like elemental analysis, FT‐IR spectroscopy, and single‐crystal X‐ray analysis. The X‐ray structural analysis revealed that C1 is a dinuclear complex realized through one bridging nitrite anion, whereas for C2, nitrate anions bridge the complexes to accomplish a 1D coordination polymer. C1 and C2 when slashed down by rapid and green mechanical method by using a simple hand grinding technique, mortar and pestle, resulted in NC1 and NC2 nanoparticles, whose average size was characterized by PXRD, SEM, and DLS. As far as we know, this is the first report where the nano‐formulation has been used while maintaining the structural integrity of the Schiff base complex. The proliferative properties of these complexes have been assessed in vitro using human lung carcinoma cell line A549. Being a polymer, the number of metal centers in NC2 is much higher; accordingly, this complex is more vital in terms of biological activity in comparison with NC1 . Abstract : A facile green hand grinding technique has been adopted to synthesize two structurally different nanoscale copper(II) Schiff base complexes. In A549 cell line nano‐C2 (NC2 ) induces apoptosis via loss of mitochondrial membrane potential and elevation of the ROS level.