Kinetics of Plasma HIV Rebound in the Era of Modern Antiretroviral Therapy. (22nd May 2020)

• Record Type: Journal Article
• Authors: Sneller, Michael C; Huiting, Erin D; Clarridge, Katherine E; Seamon, Catherine; Blazkova, Jana; Justement, Jesse S; Shi, Victoria; Whitehead, Emily J; Schneck, Rachel F; Proschan, Michael; Moir, Susan; Fauci, Anthony S; Chun, Tae-Wook
• Is Part Of: Journal of infectious diseases. Volume 222:Number 10(2020)
• Page Start: 1655
• Page End: 1659
• Publication Date: 2020-05-22
• Subjects: human immunodeficiency virus -- analytical treatment interruption -- antiretroviral therapy; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa270
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Historical data regarding time to viral rebound following analytical treatment interruption (ATI) have been used to determine therapeutic efficacy in HIV cure trials; however, such data were collected from studies conducted a decade or more ago and included participants receiving older antiretroviral therapy (ART) regimens with infrequent virologic monitoring. We conducted a study of 22 HIV-infected participants receiving modern ART to determine the kinetics of plasma viral rebound following ATI. Our data suggest that modern ART does not alter kinetics of viral rebound when compared to previous regimens and that immunologic interventions may be necessary to achieve ART-free virologic remission. Clinical Trials Registration ClinicaTrials.gov identifier: NCT03225118.