LATE-ONSET CHOROIDAL METASTASIS FROM BREAST CANCER. Issue Volume 12:Issues 4(2018) (2018)

• Record Type: Journal Article
• Authors: Levison, Ashleigh L.; Erenler, Feyza; Zhao, Yue; Martin, Daniel F.; Lowder, Careen; Budd, G. Thomas; Singh, Arun D.
• Is Part Of: Retinal cases & brief reports. Volume 12:Issues 4(2018)
• Publication Date: 2018
• Subjects: choroidal metastasis -- breast cancer -- hormone receptor positive -- hormonal therapy -- aromatase inhibitors -- late onset -- sub clinical metastatic disease -- long survival; Retina -- Diseases -- Periodicals; Retina -- Periodicals; Retinal Diseases -- Periodicals; Retina -- Case Reports; Retinal Diseases -- Case Reports; 617.7
• DOI: 10.1097/ICB.0000000000000516
• Languages: English
• ISSNs: 1935-1089

Abstract

Abstract : Purpose: Report occurrence of late-onset choroidal metastasis from breast cancer. Methods: Retrospective chart review. Results: The authors report 3 patients with choroidal metastasis from breast cancer that presented more than 20 years after diagnosis of the primary tumor. The choroidal metastases were the presenting feature of metastatic disease in all three patients, but after imaging, all patients had metastasis elsewhere as well. Two of the patients' tumors were known, ER+, and the hormone receptor status of the third patient was unknown. All three patients were treated with aromatase inhibitors with good response. Conclusion: Late onset of metastatic disease, an excellent response to hormonal therapy, and a prolonged survival despite presence of systemic disease suggests a milder variant within the broad category of breast cancer patients with uveal metastases. Awareness of this entity can minimize the risk of misdiagnosis and avoid potentially toxic local therapy. Abstract : Breast cancer is a common cause of uveal metastases. Here the authors present 3 patients with late onset uveal metastasis from breast cancer that presented more than 20 years after original diagnosis. All three patients have done well with aromatase inhibitors.