SpRY: Engineered CRISPR/Cas9 Harnesses New Genome-Editing Power. Issue 8 (August 2020)
- Record Type:
- Journal Article
- Title:
- SpRY: Engineered CRISPR/Cas9 Harnesses New Genome-Editing Power. Issue 8 (August 2020)
- Main Title:
- SpRY: Engineered CRISPR/Cas9 Harnesses New Genome-Editing Power
- Authors:
- Zhang, Dangquan
Zhang, Baohong - Abstract:
- Abstract : Due to protospacer adjacent motif (PAM) requirements, CRISPR/Cas9 cannot access many genetic loci. A recent study by Walton et al. structurally engineered Streptococcus pyogenes Cas9 (SpCas9) to near-PAMless SpRY that can target most DNA sequences with high editing efficiency and flexibility. This newly engineered SpRY will potentially expand genome-editing capabilities for basic and applied research.
- Is Part Of:
- Trends in genetics. Volume 36:Issue 8(2020)
- Journal:
- Trends in genetics
- Issue:
- Volume 36:Issue 8(2020)
- Issue Display:
- Volume 36, Issue 8 (2020)
- Year:
- 2020
- Volume:
- 36
- Issue:
- 8
- Issue Sort Value:
- 2020-0036-0008-0000
- Page Start:
- 546
- Page End:
- 548
- Publication Date:
- 2020-08
- Subjects:
- genome editing -- CRISPR/Cas9 -- gene function study -- PAM requirement -- SpRY
Genetics -- Periodicals
576.5 - Journal URLs:
- http://www.sciencedirect.com/science/journal/01689525 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.tig.2020.05.001 ↗
- Languages:
- English
- ISSNs:
- 0168-9525
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 9049.598000
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British Library STI - ELD Digital store - Ingest File:
- 21395.xml