Functional magnetic resonance imaging of brain activity during hybrid assistive limb intervention in a chronic spinal cord injury patient with C4 quadriplegia. (May 2022)

• Record Type: Journal Article
• Authors: Saotome, Kousaku; Matsushita, Akira; Eto, Fumihiko; Shimizu, Yukiyo; Kubota, Shigeki; Kadone, Hideki; Ikumi, Akira; Marushima, Aiki; Masumoto, Tomohiko; Koda, Masao; Takahashi, Hiroshi; Miura, Kosei; Matsumura, Akira; Sankai, Yoshiyuki; Yamazaki, Masashi
• Is Part Of: Journal of clinical neuroscience. Volume 99(2022)
• Page Start: 17
• Page End: 21
• Publication Date: 2022-05
• Subjects: Hybrid assistive limb (HAL) -- Functional magnetic resonance imaging -- Spinal cord injury -- Brain activity -- Laterality index; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2022.02.027
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: A complete C4 quadriplegia patient underwent gait training using robot suit HAL. We evaluated his brain activity using task-induced functional MRI. His cerebral cortex was hyperactive during the imagery task. His cortical activation was reduced with the progression of the HAL treatment. Abstract: Hybrid assistive limb (HAL) is a wearable robot, which has recently been used for the treatment of patients with movement disorders including spinal cord injury (SCI). Although several studies have indicated the effectiveness of HAL for SCI patients, changes in brain activity during the HAL intervention have not yet been fully characterized. A 19-year-old man with a chronic SCI resulting in complete C4 quadriplegia underwent five weeks of HAL training for a total of ten sessions. We evaluated his brain activity using task-induced functional MRI (fMRI) after the fourth, sixth and tenth HAL sessions. We also assessed the spasticity of this patient using the modified Ashworth scale (mAs). As controls for the task-induced fMRI, we examined the brain activity in two healthy subjects. The fMRI findings indicated an increased response to a motor imagery task in the patient's cerebral cortex compared to controls. In addition, the activation pattern in his cortex changed during the five weeks of HAL intervention. We observed increased cerebral lateralization in his primary motor cortex. We also found that the laterality index calculated for the precentral gyrus had a significant negative correlation with the total mAs score over the course of the HAL treatment. Our results indicate that the cerebral cortex of the present SCI patient was hyperactive during the imagery task, and the cortical activation was reduced with progression of the HAL treatment.