Independent risk factors of COVID-19 pneumonia in vaccinated Mexican adults. (May 2022)

• Record Type: Journal Article
• Authors: Murillo-Zamora, Efrén; Sánchez-Piña, Ramón Alberto; Trujillo, Xóchitl; Huerta, Miguel; Ríos-Silva, Mónica; Mendoza-Cano, Oliver
• Is Part Of: International journal of infectious diseases. Volume 118(2022)
• Page Start: 244
• Page End: 246
• Publication Date: 2022-05
• Subjects: COVID-19 -- Pneumonia -- Vaccination -- Smoking -- Obesity -- Diabetes Mellitus, Type 2; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2022.02.003
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: The availability of vaccines against COVID-19 represent a major step towards ending the pandemic Vaccine effectiveness may be affected by host factors Protective measures should be taken to reduce the risk of infection among vaccinated subjects Abstract: Objectives: To evaluate host factors associated with the risk of coronavirus disease 2019 (COVID-19) pneumonia in vaccinated adults. Methods: A cohort study was conducted in Mexico, and data from 1607 adults with confirmed illness, with a positive history of COVID-19 vaccination, were analyzed. Risk ratios (RR) and 95% confidence intervals (CI) were computed as a measure of the significance of the associations between putative risk factors and the prevalence of COVID-19 pneumonia in vaccinated subjects. Results: The overall risk of pneumonia was 1.98 per 1000 person-days. In the multiple regression analysis, older subjects, those with a history of smoking (current), obesity, and type 2 diabetes mellitus were at increased risk of pneumonia. Conclusions: Our results suggest that the effectiveness of COVID-19 vaccines may be reduced in a subset of adults who are older aged, smokers, obese, or have type 2 diabetes mellitus.