Long-term benefits of probiotics and calcium supplementation during childhood, and other biomedical and socioenvironmental factors, on adolescent neurodevelopmental outcomes. (April 2022)

• Record Type: Journal Article
• Authors: Rianda, Davrina; Suradijono, Sri Hartati R.; Setiawan, Evania A.; Susanto, Fenny; Meilianawati, Meilianawati; Prafiantini, Erfi; Kok, Frans J.; Shankar, Anuraj H.; Agustina, Rina
• Is Part Of: Journal of functional foods. Volume 91(2022)
• Publication Date: 2022-04
• Subjects: BDNF -- Calcium -- Casei -- Cognition -- Probiotic -- Reuteri; ADHD attention deficit hyperactivity disorder -- ASD autism spectrum disorder -- BDNF brain-derived neurotrophic factor -- BMI body mass index -- CDI Children's Depression Inventory -- CFU colony-forming unit -- CREB cAMP response element-binding protein -- CRS-I calcium response sequence-I -- DQI-A Diet Quality Index for Adolescents -- EA-HOME-A Abbreviated Early Adolescent Home Observation and Measurement of the Environment -- GLM general linear model -- LC low calcium -- LMICs low-to-middle-income countries -- LPS lipopolysaccharides -- PAQ-C Physical Activity Questionnaire for Older Children -- RC regular calcium -- RCTs randomized controlled trials -- RPM Raven's Progressive Matrices -- SCFAs short-chain fatty acids -- SD standard deviation -- SDQ Strength and Difficulties Questionnaire; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2022.105014
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Probiotics supplementation in childhood improve adolescent neurodevelopment. The effects of probiotics on neurodevelopment are strain-specific. Low calcium supplementation resulted in lower BDNF as compared to regular calcium. Combined childhood interventions with probiotics and socioenvironmental components are warranted. Abstract: We evaluated the impact of 6-month probiotics and calcium supplementation at 1–6 years of age on neurodevelopment in adolescence, along with the effects of other biomedical and socioenvironmental factors. We re-enrolled 238 adolescents 10-years after supplementation with low-lactose milk with either low calcium (LC; ∼50 mg/d; n = 53), regular calcium (RC; ∼440 mg/d; n = 70), RC with 5x10 8 CFU/d Lactobacillus reuteri DSM17938 (reuteri; n = 55), or RC with 5x10 8 CFU/d L. casei CRL431 (casei; n = 60). Compared to RC, the casei group scored 0.38 SD (effect size, 0.04–0.72) higher on the Raven's Progressive Matrices; the reuteri group was 0.38 SD (0.01–0.75) lower on the Children's Depression Inventory; and the LC and younger adolescents in the reuteri group were 0.36 (0.01–0.71) and 0.49 SD (0.02–0.95) lower in brain-derived neurotrophic factor. Diet quality, physical activity, and home environment contributed similar effect sizes. Probiotics supplementation in childhood have strain-specific long-term neurodevelopmental benefits and integration with socioenvironmental interventions are warranted.