Gut microbiome-modulating properties of a polyphenol-enriched dietary supplement comprised of hibiscus and lemon verbena extracts. Monitoring of phenolic metabolites. (April 2022)

• Record Type: Journal Article
• Authors: Silva, Mariana; Cueva, Carolina; Alba, Claudio; Rodriguez, Juan Miguel; de Pascual-Teresa, Sonia; Jones, Jonathan; Caturla, Nuria; Victoria Moreno-Arribas, M.; Bartolomé, Begoña
• Is Part Of: Journal of functional foods. Volume 91(2022)
• Publication Date: 2022-04
• Subjects: Non-communicable diseases -- Obesity -- Hibiscus -- Lemon verbena -- Polyphenols -- Phenylpropanoids -- Anthocyanins -- Faecal fermentation -- Gut microbiota -- Phenolic metabolites; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2022.105016
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Metabolaid® is a dietary supplement comprising hibiscus and lemon verbena extracts. Metabolaid®, in a dose-dependent manner, modulated the gut bacteriome. Phenolic compounds in Metabolaid® were rapidly metabolized by the gut microbiota. Metabolaid® promoted increases in SCFAs production, particularly butyric acid. Abstract: This paper investigates the impact of a polyphenol-enriched supplement comprised of hibiscus ( Hibiscus sabdariffa ) and lemon verbena ( Lippia Citriodora ) (brand name Metabolaid®) on gut microbiota composition and functionality, by performing fermentations with human faecal microbiota under gut-simulated conditions. Results indicated that Metabolaid®, in a dose-dependent manner, modulated the gut bacteriome to higher relative abundances of some major genera (>3% of relative abundance) such as Bifidobacterium, Blautia and Faecalibacterium and of other minor genera such as Prevotella and Akkermansia . Metabolaid® also promoted increases in short-chain fatty acids (SCFAs) production, particularly butyric acid. On the other hand, it was confirmed that the compounds present in the Metabolaid® supplement (anthocyanins, verbascoside and hibiscus acid) were rapidly metabolized by the gut microbiota. Overall, these results reveal a certain level of gut microbiota-modulating properties of Metabolaid® that could be implicated, at least partially, in the mechanisms behind the potential beneficial effects of this supplement in obesity.