Association between osteoarthritis-related serum biochemical markers over 11 years and knee MRI-based imaging biomarkers in middle-aged adults. Issue 5 (May 2022)

• Record Type: Journal Article
• Authors: Singh, A.; Venn, A.; Blizzard, L.; Jones, G.; Burgess, J.; Parameswaran, V.; Cicuttini, F.; March, L.; Eckstein, F.; Wirth, W.; Ding, C.; Antony, B.
• Is Part Of: Osteoarthritis and cartilage. Volume 30:Issue 5(2022)
• Page Start: 756
• Page End: 764
• Publication Date: 2022-05
• Subjects: Osteoarthritis -- Biomarkers -- Magnetic resonance imaging (MRI) -- Cartilage degradation -- Metalloproteinase; ASHFS Australian Schools Health and Fitness Survey -- BMI Body Mass Index -- BML Bone Marrow Lesions -- BOKS Boston Osteoarthritis Knee Study -- CATI Computer-Assisted Telephone Interview -- CDAH Childhood Determinants of Adult Health -- COMP Cartilage Oligomeric Matrix Protein -- ELISA Enzyme-Linked Immunosorbent Assay -- FNIH Foundation For The National Institutes Of Health -- GBD Global Burden Of Diseases, Injuries, And Risk Factors Study -- HA Hyaluronan -- ICC Intraclass Correlation Coefficient -- JSN Joint Space Narrowing -- LFTC Lateral Femorotibial Compartment -- MFTC Medial Femorotibial Compartment -- MMP Matrix Metalloproteinase -- MRI Magnetic Resonance Imaging -- OAI Osteoarthritis Initiative -- OARSI Osteoarthritis Research Society International -- RHHRF Royal Hobart Hospital Research Foundation; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Arthrose -- Périodiques; Articulations -- Maladies -- Périodiques; 616.7223005
• DOI: 10.1016/j.joca.2022.02.616
• Languages: English
• ISSNs: 1063-4584

Abstract

Summary: Objective: To describe the associations between osteoarthritis (OA)-related biochemical markers (COMP, MMP-3, HA) and MRI-based imaging biomarkers in middle-aged adults over 10–13 years. Methods: Blood serum samples collected during the Childhood Determinants of Adult Health (CDAH)-1 study (year:2004–06; n = 156) and 10–13 year follow-up at CDAH-3 ( n = 167) were analysed for COMP, MMP-3, and HA using non-isotopic ELISA. Knee MRI scans obtained during the CDAH-knee study (year:2008–10; n = 313) were assessed for cartilage volume and thickness, subchondral bone area, cartilage defects, and BML. Results: In a multivariable linear regression model describing the association of baseline biochemical markers with MRI-markers (assessed after 4-years), we found a significant negative association of standardised COMP with medial femorotibial compartment cartilage thickness (β:-0.070; 95%CI:-0.138, -0.001), and standardised MMP-3 with patellar cartilage volume (β:-141.548; 95%CI:-254.917, -28.179) and total bone area (β:-0.729; 95%CI:-1.340, -0.118). In multivariable Tobit regression model, there was a significant association of MRI-markers with biochemical markers (assessed after 6–9 years); a significant negative association of patellar cartilage volume (β:-0.001; 95%CI:-0.002, -0.00004), and total bone area (β:-0.158; 95%CI-0.307, -0.010) with MMP-3, and total cartilage volume (β:-0.001; 95%CI:-0.001, -0.0001) and total bone area (β:-0.373; 95%CI:-0.636, -0.111) with COMP. No significant associations were observed between MRI-based imaging biomarkers and HA. Conclusion: COMP and MMP-3 levels were negatively associated with knee cartilage thickness and volume assessed 4-years later, respectively. Knee cartilage volume and bone area were negatively associated with COMP and MMP-3 levels assessed 6–9 years later. These results suggest that OA-related biochemical markers and MRI-markers are interrelated in early OA.