SAT0310 The associations of serum il18 and osteoprotegerin (OPG) levels with the lipid profile in psoriatic arthritis (PSA) patients. (12th June 2018)

• Record Type: Journal Article
• Authors: Bonek, K.; Gluszko, P.; Kontny, E.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 1019
• Page End: 1020
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.4647
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: We have previously found that IL-18 and OPG serum concentrations are correlated with cardiovascular (CV) risk in psoriatic arthritis but not in ankylosing spondylitis (AS) patients. 1 Objectives: To investigate whether in PsA patients the association of OPG and IL-18 with CV risk is mediated by an impact of these cytokines on lipid profile changes. Methods: 49 patients with PsA (25 M/24 F) with (n=10) and without (n=39) coronary heart disease (CHD), and 25 sex and age matched (mean age 44, 4 vs 43, 4 years) patients with AS were enrolled. Disease activity was measured by DAPSA (25, 17±19, 9) in PsA group and by BASDAI (5, 37±2) and ASDAS- CRP (3, 18±1) in AS group. The lipid profile (triglycerides – TG, total cholesterol – tChol, low- and high-density lipoprotein – LDL and HDL, respectively), systemic inflammation markers and cytokines (OPG, IL-18) were measured in patients serum samples. Atherogenic index (AI=tChol/HDL) was calculated. Statistical analysis was performed using Mann-Whitney U-test and Spearman's Rank test. Data are expressed as mean values. Results: Patients with PsA presented more atherogenic lipid profile than AS patients because of their higher TG levels (153 vs 126, 6 mg/dl; p=0, 05) and AI values (3, 83 vs 3, 24; p=0, 05) while lower HDL concentrations (51, 6 vs 61, 4 mg/dl; p=0, 04). Compared to AS group, PsA patients were characterised by higher IL-18 (235 vs 208 pg/ml; p<0, 05) but lower OPG (815 vs 1660 pg/ml; p<0, 05) serum levels. In PsA patients without CHD, serum OPG positively but moderately correlated with LDL (r=0, 3; p=0, 05), TG (r=0, 43; p=0, 007) and AI (r=0, 45 p=0, 004). Moreover, in this PsA patients subgroup we confirmed previously observed 1 inverse correlation of IL-18 with HDL levels (r=-0, 34; p=0, 05) and positive correlation of this cytokine with both TG levels (r=0, 37; p=0, 04) and AI values (r=0, 53; p=0, 002). Interestingly, similar but stronger associations of IL-18 with HDL levels (r=-0, 88; p=0, 004) and AI values (r=0, 88; p=0, 004) were presently found in PsA patients with accompanied CHD. Consistently with our previous report, 1 we failed to find any correlations between CV risk, lipid profile, and tested cytokines serum concentrations in patients with AS. Conclusions: We report that in PsA, but not AS, patients serum IL-18 and OPG concentrations are correlated with an altered and pro-atherogenic lipid profile. These associations are stronger in patients with concomitant CHD. Thus, present results explain partially the way by which these cytokine contribute to CV complications in PsA. Reference: [1] Kontny E, et al. Association of serum osteoprotegerin and IL-18 concentrations with cardiovascular risk in ankylosing spondylitis and psoriatic arthritis. Ann Rheum Dis2017;76(suppl 2):1310–1311AB0733. Disclosure of Interest: None declared