Neurotoxicity of β-HgS differs from environmental mercury pollutants (MeHgCl and HgCl2) in Neuro-2a cell. Issue 7 (3rd October 2021)

• Record Type: Journal Article
• Authors: Xia, Zhenghua; Bi, Hongtao; Li, Cen; Geng, Lujing; Usman, Muhammad; Du, Yuzhi; Wei, Lixin
• Is Part Of: International journal of environmental health research. Volume 31:Issue 7(2021)
• Page Start: 861
• Page End: 871
• Publication Date: 2021-10-03
• Subjects: Β-HgS -- MeHgCl -- HgCl2 -- neurotoxiciry -- Neuro-2a; Environmental health -- Periodicals; 363.7
• DOI: 10.1080/09603123.2019.1692792
• Languages: English
• ISSNs: 0960-3123

Abstract

ABSTRACT: β-HgS, differing from environmental mercury pollutants (MeHgCl and HgCl2 ) in chemical form, is used as traditional medicine in Asian countries for thousands of years. In this study, Neuro-2a cells were exposed to β-HgS, MeHgCl and HgCl2 (5 µM) for 6–24 h. The cell viability of β-HgS was higher than MeHgCl with 25.9% and 72.4% in 12 h and 24 h respectively. As the incubation time increased, MeHgCl had obvious damage to cell morphology, decreased the ratio of Bcl-2 and Bak and increased the expressions of TNF-α, IL-6 and IL-1β significantly. Furthermore, the expressions of IL-1β and IL-6 in HgCl2 group were increased significantly in 6 h and 24 h. The apoptotic rates in MeHgCl and HgCl2 group were respectively higher than β-HgS with 32.2% and 7.30% in 24 h. Our findings indicate that β-HgS is much less neurotoxicity than MeHgCl and HgCl2 in Neuro-2a cells.