Association among blood BPDE-DNA adduct, serum interleukin-8 (IL-8) and DNA strand breaks for children with pulmonary diseases. Issue 7 (3rd October 2021)

• Record Type: Journal Article
• Authors: Kuang, Hongxuan; Dai, Yanyan; Ding, Xiang; Li, Yonghong; Cha, Caihui; Jiang, Wenhui; Zhang, Haibin; Zhou, Wenji; Zeng, Yingwei; Pang, Qihua; Fan, Ruifang
• Is Part Of: International journal of environmental health research. Volume 31:Issue 7(2021)
• Page Start: 823
• Page End: 834
• Publication Date: 2021-10-03
• Subjects: Benzo[a]pyrene -- BPDE-DNA adduct -- peripheral blood lymphocytes -- DNA strand breaks -- pulmonary inflammation; Environmental health -- Periodicals; 363.7
• DOI: 10.1080/09603123.2019.1690638
• Languages: English
• ISSNs: 0960-3123

Abstract

ABSTRACT: Exposure to benzo[a]pyrene (B[a]P) may be a risk factor for pulmonary diseases. To investigate the correlations among B[a]P exposure level, DNA strand breaks and pulmonary inflammation, we recruited 83 children diagnosed with pulmonary diseases and 63 healthy children from Guangzhou, China. Results showed that the levels of Benzo[a]pyrene diol epoxide (BPDE) DNA adduct in blood and IL-8 in serum in case group were significantly higher than those in control group ( p < 0.01). Moreover, levels of atmospheric B[a]P in case group was about twice of those in control group, which was consistent with the levels of BPDE-DNA adduct in blood. Significant positive correlations were observed among the levels of BPDE-DNA adduct, IL-8 and DNA strand breaks ( p < 0.05). Our findings indicate that environmental air is an important exposure source of B[a]P and higher B[a]P exposure may contribute to the occurrence of pulmonary inflammation and lead to high health risks.