An L-tert-leucine derived urea catalyzed asymmetric synthesis of acylclic N, N′-ketals derived from aryl amines and isatin-derived ketimines. (1st January 2022)

• Record Type: Journal Article
• Authors: Liu, Shuo; Wang, Jingdong; Wei, Zhonglin; Cao, Jungang; Liang, Dapeng; Lin, Yingjie; Duan, Haifeng
• Is Part Of: Tetrahedron. Volume 103(2022)
• Publication Date: 2022-01-01
• Subjects: α-amino acids skeleton -- Urea -- Isatin-derived ketimines -- N, N′-ketals; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2021.132206
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: An asymmetric synthesis of N, N′ -ketal compounds derived from isatin-derived ketimines and aryl amines has been developed using an inexpensive and readily available L-tert -leucine derived urea catalyst. Using this asymmetric catalytic synthetic method, a series of 3-substituted 3-amino-2-oxoindole derivatives containing an N, N ′-ketal motif were obtained in high yields with high enantioselectivities. Graphical abstract: Image 1