AB0885 Characteristics of juvenile onset hip arthritis in patients with spondyloarthritis. (12th June 2018)

• Record Type: Journal Article
• Authors: Hamdi, W.; Ben Saad, R.; Riahi, H.; Maatallah, K.; Kaffel, D.; Bouaziz, T.; Ledab, L.; Kchir, M.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 1568
• Page End: 1568
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.5872
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Axial spondyloarthritis (AS) is a chronic inflammatory rheumatic disease that affects the axial skeleton. It typically occurs in the late teens or early twenties and rarely in childhood, defining the juvenile onset (JoAS). The adult-onset AS (AoAS) and Juvenile-onset (JoAS) may share many common features including hip involvement. But their impact on function and quality of life may differ. Objectives: To compare demographic, clinic and functional outcome of patients with hip involvement in JoAS, with that of patients with AoAS Methods: Cross-sectional study including patients with AS according to the, ASAS criteria of 2009 with hip involvement. The juvenile onset of coxitis was defined by an onset before 16 years of age. An analysis of demographic and clinical comparisons between the two groups was performed including HLA B27 status. Mobility spine outcomes were assessed by the Bath AS Metrology Index (BASMI) and radiographic disease severity by the Bath AS Radiology Index (BASRI). Results: There were 100 AS aged on average 36.4±12, 2 years old. 16–69 The sex ratio was 4.6. The mean duration of progression of AS was 10.93±9, 89 years [0.5–24]. It was a JoAS in 15 cases. All patients had a hip involvement. The juvenile onset of hip arthritis was associated with male gender (p=0, 042), younger age of patient with AS at the time of recruitment (p=0, 007), less severe clinical spinal involvement assessed by schober index (p=0, 029) and more frequent and severe enthesitis assessed by MASES (p=0, 024). Extra-articular manifestations were significantly more frequent in patients with juvenile onset of hip arthritis (p=0, 008). Otherwise the comparison of the two groups showed no difference in the presence of uveitis (p=0, 407) and pulmonary involvement (p=0, 097). HLAB27 antigen was significantly more common in JoAS (p=0, 037). BASRI and BASMI as well as ESR and CRP, were comparable between the two groups (p=0, 976, p=0, 626, p=1, 000, respectively) Conclusions: Hip involvement is common in the AS, particularly in JoAS. Our study showed that juvenile onset hip arthritis was associated with male gender, less severe spine involvement, enthesitis and the presence of HLA B27. This would help physicians to identify patients at higher risk of developing hip involvement, to enable early diagnosis. References: [1] Gensler LS, Ward MM, Reveille JD, Learch TJ, Weisman MH, Davis JC, Jr. Clinical, radiographic and functional differences between juvenile-onset and adult-onset ankylosing spondylitis: results from the PSOAS cohort. Ann Rheum Dis. 2008;67(2):233–7. [2] Stone M, Warren RW, Bruckel J, Cooper D, Cortinovis D, Inman RD. Juvenile-onset ankylosing spondylitis is associated with worse functional outcomes than adult-onset ankylosing spondylitis. Arthritis Rheum. 2005;53(3):445–51. Disclosure of Interest: None declared