Bioactive NIR‐II Light‐Responsive Shape Memory Composite Based on Cuprorivaite Nanosheets for Endometrial Regeneration. Issue 12 (26th February 2022)

• Record Type: Journal Article
• Authors: Dong, Chenle; Yang, Chen; Younis, Muhammad Rizwan; Zhang, Jing; He, Gang; Qiu, Xingdi; Fu, Lian‐Hua; Zhang, Dong‐Yang; Wang, Hao; Hong, Wenli; Lin, Jing; Wu, Xueqing; Huang, Peng
• Is Part Of: Advanced science. Volume 9:Issue 12(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-26
• Subjects: cuprorivaite nanosheets -- endometrial regeneration -- intrauterine adhesions -- NIR‐II light‐responsive -- shape memory; Science -- Periodicals; 505
• DOI: 10.1002/advs.202102220
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Intrauterine adhesions (IUAs) caused by mechanical damage or infection increase the risk of infertility in women. Although numerous physical barriers such as balloon or hydrogel are developed for the prevention of IUAs, the therapeutic efficacy is barely satisfactory due to limited endometrial healing, which may lead to recurrence. Herein, a second near‐infrared (NIR‐II) light‐responsive shape memory composite based on the combination of cuprorivaite (CaCuSi4 O10 ) nanosheets (CUP NSs) as photothermal conversion agents and polymer poly(d, l ‐lactide‐ co ‐trimethylene carbonate) (PT) as shape memory building blocks is developed. The as‐prepared CUP/PT composite possesses excellent shape memory performance under NIR‐II light, and the improved operational feasibility as an antiadhesion barrier for the treatment of IUAs. Moreover, the released ions (Cu, Si) can stimulate the endometrial regeneration due to the angiogenic bioactivity. This study provides a new strategy to prevent IUA and restore the injured endometrium relied on shape memory composite with enhanced tissues reconstruction ability. Abstract : A second near‐infrared light‐responsive shape memory composite, which is composed of cuprorivaite (CaCuSi4 O10 ) nanosheets as photothermal conversion agents and polymer poly(d, l ‐lactide‐ co ‐trimethylene carbonate) as shape memory building blocks, is developed for intrauterine adhesions prevention and endometrial regeneration.