FRI0006 Association between interleukin-10 polymorphisms and juvenile idiopathic arthritis: a meta-analysis. (12th June 2018)

• Record Type: Journal Article
• Authors: Jung, J.H.; Kim, J.-H.; Song, G.G.; Choi, S.J.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 550
• Page End: 550
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.2211
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Juvenile idiopathic arthritis (JIA) is the most common chronic arthritis in children. JIA is a heterogeneous group of complex diseases and the result of a combination of genetic and environmental factors. Multiple genes contribute to the risk of developing JIA. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is associated with inflammatory diseases. IL-10 is considered a candidate gene for JIA based on its chromosomal location and functional relevance. Objectives: IL-10 genetic polymorphisms associated with JIA were previously identified, especially in haplotypes studies. However, results from different studies have been inconsistent. Thus, we investigated whether IL-10 polymorphisms were associated with susceptibility to JIA. Methods: A meta-analysis was conducted of the associations between the IL-10–1082G/A, −819 C/T, and −592 C/A polymorphisms and JIA. A total of eight studies involving 1495 patients and 1670 controls were considered in the meta-analysis. This meta-analysis was conducted based on the Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) guidelines. Results: There was no association between the IL-10–1082G/A, −819 C/T, and −592 C/A polymorphisms and JIA in allele contrast and any of the genetic models (allele contrast: OR=0.90, 95% CI=0.79–1.02, p=0.09; OR=0.97, 95% CI=0.83–1.13, p=0.68; OR=0.92, 95% CI=0.81–1.06, p=0.24, respectively). Subgroup analyses revealed a significant association between the IL-10–1082 G allele and systemic JIA (OR=0.80, 95% CI=0.67–0.96, p=0.02). Meta-analysis of the IL-10 haplotype revealed no association between GCC, ACC, and ATA haplotypes and JIA. Conclusions: This meta-analysis indicated lack of associations between IL-10 polymorphisms and susceptibility to JIA. However, there was a significant association between IL-10–1082 G allele and systemic JIA. References: [1] Harsini S, et al. Interleukin 10 and transforming growth factor beta 1 gene polymorphisms in juvenile idiopathic arthritis. Bratisl Lek Listy2016;117:258–262. [2] Cinek O, et al. Association of single nucleotide polymorphisms within cytokine genes with juvenile idiopathic arthritis in the Czech population. J Rheumatol2004;31:1206–1210. [3] Fathy MM, et al. Association of IL-10 gene polymorphisms and susceptibility to juvenile idiopathic arthritis in Egyptian children and adolescents: a case-control study. Ital J Pediatr2017;43:9. Acknowledgements: No grants or other support were received for the conduction of this study. Disclosure of Interest: None declared