Neuropilin‐1‐Mediated SARS‐CoV‐2 Infection in Bone Marrow‐Derived Macrophages Inhibits Osteoclast Differentiation (Adv. Biology 5/2022). Issue 5 (9th May 2022)

• Record Type: Journal Article
• Authors: Gao, Junjie; Mei, Hong; Sun, Jing; Li, Hao; Huang, Yuege; Tang, Yanhong; Duan, Linwei; Liu, Delin; Pang, Yidan; Wang, Qiyang; Gao, Youshui; Song, Ke; Zhao, Jincun; Zhang, Changqing; Liu, Jia
• Is Part Of: Advanced biology. Volume 6:Issue 5(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-09
• Subjects: Molecular biology -- Periodicals; Systems biology -- Periodicals; Biological systems -- Periodicals; Biotechnology -- Periodicals; Bioengineering -- Periodicals; Biomedical engineering -- Periodicals; 660.6
• DOI: 10.1002/adbi.202270051
• Languages: English
• ISSNs: 2701-0198

Abstract

Abstract : Bone Marrow‐Derived Macrophages SARS‐CoV‐2 In article 2200007, Zhao, Zhang, Liu, and co‐workers teamed up to investigate SARS‐CoV‐2 infection in bone marrow‐derived macrophages (BMMs). They find that SARS‐CoV‐2 infects BMMs in a neuropilin‐1 (NRP1)‐dependent manner (insert: red, SARS‐CoV‐2 and its spike protein; green, BMM and its NRP1 protein). Interestingly, SARS‐CoV‐2 infection could inhibit the differentiation of BMMs into osteoclasts (bottom, blue).