Enzyme‐Engineered Conjugated Polymer Nanoplatform for Activatable Companion Diagnostics and Multistage Augmented Synergistic Therapy. Issue 18 (25th March 2022)

• Record Type: Journal Article
• Authors: Wu, Jiayingzi; Zhang, Yafei; Jiang, Kejia; Wang, Xiaoyu; Blum, Nicholas Thomas; Zhang, Jing; Jiang, Shanshan; Lin, Jing; Huang, Peng
• Is Part Of: Advanced materials. Volume 34:Issue 18(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-25
• Subjects: companion diagnostics -- glucose oxidase -- pH‐responsive -- polyaniline -- synergistic therapy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202200062
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Companion diagnostics (CDx) provides critical information for precision medicine. However, current CDx is mostly limited to in vitro tests, which cannot accurately evaluate the disease progression and treatment response in real time. To overcome this challenge, herein a glucose oxidase (GOx)‐engineered conjugated polymer (polyaniline, PANI) nanoplatform (denoted as PANITG) is reported for activatable imaging‐based CDx and multistage augmented photothermal/starvation synergistic therapy. PANITG comprises a pH‐activatable conjugated polymer as a photothermal convertor and photoacoustic (PA) emitter, a GOx as a cancer starvation inducer as well as a H2 O2 and acid producer, and a H2 O2 ‐cleavable linker as a "switch" for GOx activity. The in vivo PA imaging and photothermal therapy abilities are activated by acidic tumor microenvironment and self‐augmented by the reaction between GOx and glucose. Meanwhile, the photothermal effect will enhance the GOx activity in turn. Such multistage augmentation of the therapeutic effects will facilitate effective cancer management. In addition, the in vivo PA imaging with PANITG reveals the tumor pH level which is correlated to the efficiency of the photothermal therapy and to the catalytic activity of GOx at each stage, enabling real‐time activatable CDx. Abstract : A glucose‐oxidase‐based nanoplatform simultaneously realizes photoacoustic‐imaging‐based companion diagnostics, photothermal/starvation therapy, and real‐time monitoring of cancer treatment.