THU0163 Extra-articular manifestations in rheumatoid arthritis: a comprehensive analysis in a large cohort. (12th June 2018) - Bonfiglioli, K.R.
Abstract : Background: Although Rheumatoid Arthirtis (RA) extra-articular manifestations (ExRA) occurrence have been decreasing over time, they are still a major mortality risk factor for patients, and also a challenge for rheumatologists. Objectives: To determine the prevalence of ExRA in a large cohort, and its association with several clinical data. Methods: A cross-sectional and observational study, based on a multi-centric database from a prospective cohort (The REAL – RA in real life in Brazil), in which 11 public rheumatology centres enrolled RA patients (1987 ARA or 2010 ACR-EULAR). Data collection began in 08–2015, using a single online electronic medical record, and included demographic, socioeconomic, clinical and therapeutic characteristics. Results: 1116 patients from 11 centres were included: 89% women, age [mean ±SD] 58.2±11.5 year, disease duration 14.5±12.2 year, positive Rheumatoid Factor (RF) in 77%. Regarding ExRA, 334 occurrences (detailed in table 1) were registered in 261 patients, summing for an overall prevalence of 23, 4% in our cohort. Comparison among ExRA and No-ExRA groups reveals significant higher age, disease duration, Cinical Disease Activity index (CDAI), Health Assessment Questionnaire (HAQ) and Disease Activity Index (DAS 28) in ExRA group (table 2) . Unexpectedly, some well–known factors associated with ExRA, such as Rheumatoid factor (RF) and tobacco use, were similar among the two groups. Conclusions: ExRA still shows an expressive occurrence that should not be underestimated. Our findings reinforce that long-term disease, associated with significant disability and persistent inflammatory activity, are the key factors related to ExRA development. Early aggressive treatment with effective therapies should lower the risk and severity of ExRA. Disclosure of Interest: None declared