An Engineered Protein−Au Bioplaster for Efficient Skin Tumor Therapy. Issue 16 (10th March 2022)

• Record Type: Journal Article
• Authors: Wei, Zheng; Sun, Jing; Lu, Shuang; Liu, Yawei; Wang, Bo; Zhao, Lai; Wang, Zili; Liu, Kai; Li, Jingjing; Su, Juanjuan; Wang, Fan; Zhang, Hongjie; Yang, Yang
• Is Part Of: Advanced materials. Volume 34:Issue 16(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-10
• Subjects: adhesive proteins -- bioplasters -- gold nanoparticles -- photothermal effect -- skin cancer therapy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202110062
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Melanoma is the most lethal malignancy in skin cancer and may occur at any site and express melanocytes. Due to malignant melanoma's invasion and migration nature, conventional therapies make it challenging to remove the whole tumor tissue while undertaking the high risks of tumor recurrence. Regarding the emerging targeted therapies and immunotherapy, drug resistance and low immunotherapeutic activity remain significant challenges. It is thus becoming urgently important to develop alternative strategies for melanoma therapy. Herein, a novel bifunctional protein‐based photothermal bioplaster (PPTB) is developed for non‐invasive tumor therapy and skin tissue regeneration. The complexation of adhesive protein and gold nanorods (GNRs) endow the obtained PPTB with good biocompatibility, controllable near‐infrared (NIR) light‐mediated adhesion performance, and high photothermal performance. Therefore, the PPTB bioagent facilitates skin adhesion and effectively transfers heat from skin to tumor. This behavior endows PPTB capability to eradicate skin tumors conveniently. Thus, the assembly strategy enables this hybrid bioplaster to hold great potential for skin‐related tumor treatment. Abstract : A new type of engineered protein−Au bioplaster with outstanding photothermal effect is developed. In this system, the adhesion performance can be enhanced significantly as prolonging irradiation time to achieve stable adhesion on skin surface. This further promotes the heat penetration into the skin tumor site for non‐invasive thermal eradication of melanoma.