Lithium dilution cardiac output measurements in isoflurane-anaesthetised goats: Jugular versus cephalic lithium chloride administration. (December 2021)

• Record Type: Journal Article
• Authors: Gómez Fernández, Laura; Niimura del Barrio, María Chie; Huuskonen, Vilhelmiina; Fernandez Perez, Cristina; Brama, Pieter; Hughes, Lynne
• Is Part Of: Research in veterinary science. Volume 141(2021)
• Page Start: 95
• Page End: 102
• Publication Date: 2021-12
• Subjects: Cardiac output -- Cephalic -- Goats -- Jugular -- lithium; Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; Médecine vétérinaire -- Périodiques; Médecine vétérinaire -- Recherche -- Périodiques; Diergeneeskunde; 636.089
• DOI: 10.1016/j.rvsc.2021.10.014
• Languages: English
• ISSNs: 0034-5288

Abstract

Abstract: The administration of lithium chloride (LiCl) for cardiac output (CO) measurement via a peripheral instead of a central vein has been described previously as a valid alternative route in pigs and dogs. The aim of the study was to compare CO measurements after administration of LiCl using two peripheral veins, cephalic or jugular, in goats. Ten adult, female, experimental goats undergoing bilateral stifle arthrotomy were recruited for the study. Paired CO measurements were taken two minutes apart during stable conditions in isoflurane-anaesthetised goats. Forty-two paired CO measurements were taken in total, and the median (range) of paired CO measurement per goat were 4.5 (3–6). The mean (SD) CO using the cephalic and jugular vein for injection of LiCl was 5.28 (1.29) L min −1 and 5.20 (1.24) L min −1 respectively. The Bland-Altman analysis showed an acceptable agreement with a mean bias of 1.33% with limits of agreement (LoA) of −18.43 to 21.09%. The percentage of error was 25%. The four-quadrant plot analysis showed a poor agreement (71%) between the two routes. The polar plot showed a poor trending ability. An 86% inclusion rate (18/21 points) was reached with a ± 35° radial sector size. The findings revealed that the agreement between the two routes is not as precise as the authors expected, however the results are comparable with studies published previously. Highlights: Lithium dilution cardiac output has not previously been described in goats Cephalic and jugular injection of lithium chloride give comparable results in goats Cardiac output measurements are similar to other studies in goats Peripheral catheters are less invasive and reduce instrumentation time