Enzyme replacement therapy leading to improvement in myeloma indices in a patient with concomitant Gaucher disease. Issue 5 (10th May 2022)

• Record Type: Journal Article
• Authors: Harel, Reut; Gavish, Israel; Aviv, Ariel; Greenman Maravi, Nofar; Trougouboff, Philippe; Zimran, Ari; Revel‐Vilk, Shoshana
• Is Part Of: Internal medicine journal. Volume 52:Issue 5(2022)
• Page Start: 872
• Page End: 875
• Publication Date: 2022-05-10
• Subjects: Gaucher disease -- enzyme replacement therapy -- multiple myeloma -- monoclonal gammopathy of unknown significance (MGUS) -- polyclonal gammopathy; Medicine -- Periodicals; 616
• DOI: 10.1111/imj.15781
• Languages: English
• ISSNs: 1444-0903

Abstract

Abstract: Patients with Gaucher disease (GD) have been shown previously to carry an increased risk for cancer, most commonly multiple myeloma (MM). It is currently unknown whether treatment for GD has an effect on the prevention or amelioration of MM. We present the case of a 41‐year‐old patient simultaneously diagnosed with GD and smouldering MM. Enzyme replacement therapy with Velaglucerase‐alfa significantly improved myeloma indices.