The association of OPG polymorphisms with diabetic retinopathy in Chinese population. (2nd November 2021)

• Record Type: Journal Article
• Authors: Xu, Huijuan; Li, Huan; Luo, Qian; Li, Yihui; Huang, Guo; Lei, Chuntao; Hao, Fang; Xiao, Jialing; Yang, Chen; Yu, Man; Wang, Ziyang; Shi, Yi; Zhong, Ling; Duan, Lixin; Chen, Huafu; Dezhong, Yao; Gong, Bo; Yang, Zhenglin
• Is Part Of: Ophthalmic genetics. Volume 42:Number 6(2021)
• Page Start: 659
• Page End: 663
• Publication Date: 2021-11-02
• Subjects: OPG -- polymorphism -- association -- diabetic retinopathy; Eye -- Diseases -- Genetic aspects -- Periodicals; Eye Diseases -- genetics -- Periodicals; Eye Diseases -- in infancy & childhood -- Periodicals; 617.7
• DOI: 10.1080/13816810.2021.1946702
• Languages: English
• ISSNs: 1381-6810

Abstract

ABSTRACT: Purpose: Genetic factors have been studied to be associated with diabetic retinopathy (DR). This study aimed to investigate the association between the polymorphisms in the osteoproterin ( OPG ) gene and DR in a Han Chinese population. Methods: There were 475 patients with diabetic retinopathy (DR), 478 type 2 diabetes mellitus without retinopathy (DNR) and 469 healthy controls collected in this study. OPG single-nucleotide polymorphisms (SNPs) rs2073618 and rs3134069 were genotyped by Mass ARRAY MALDI-TOF system. The genotype and allele frequencies were evaluated using the χ 2 tests. Odds ratio (OR) and 95% confidence intervals (95% CI) were calculated for the risk of genotype and allele. Results: There was a statistically significant difference for OPG SNP rs3134069 between DR cases and healthy controls in the allelic model ( P = .036, OR = 1.33, 95% CI = 1.02–1.73). The C allele frequency of this polymorphism was 0.154 in the DR cases, whereas it was 0.120 in healthy controls, suggesting a risk effect for DR. SNP rs3134069 had a significant association with DR in the dominant model ( P = .038, OR = 1.37, 95% CI = 1.02–1.84), indicating that the CC/AC genotype was more likely to suffer from DR. For rs2073618, no significant difference was identified in the allelic model ( P = .632, OR = 0.95, 95% CI = 0.78–1.16) and the four genetic models. Conclusions: This study showed that OPG SNP rs3134069 was associated with DR in the dominant model, suggesting that the OPG gene variant may be involved in the development of DR.