THU0596 Measurement of serum calprotectin mrp8/14 in paediatric patients diagnosed with juvenile idiopathic arthritis and autoinflammatory diseases. (12th June 2018)

• Record Type: Journal Article
• Authors: Murias, S.; Udaondo, C.; Alcobendas, R.M.; Remesal, A.; Pascual-Salcedo, D.
• Is Part Of: Annals of the rheumatic diseases. Volume 77(2018)Supplement 2
• Page Start: 498
• Page End: 498
• Publication Date: 2018-06-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2018-eular.4526
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: There is evidence of the correlation between serum levels of calprotectin MRP8/14 and disease activity in Juvenile Idiopathic Arthritis (JIA), but the same correlation with other rheumatic diseases in children such as autoinflammatory diseases has not been studied as much. Objectives: To analyse calprotectin MRP8/14 in serum of patients with juvenile idiopathic arthritis (JIA) and various autoinflammatory diseases with different degrees of activity. To check if there is a correlation between serum MRP8/14 and disease activity. Methods: Study in two phases: 1) Initial, transversal, in JIA and/or autoinflammatory disease patients, determining serum MRP8/14 (by ELISA test) and collecting clinical data: number of active joints, Visual Analogue Scale parents/patients (VASp), VAS physician (VASph); and analytical: C-Reactive Protein (CPR) and white cells blood count (WBC) (among others). 2) Second prospective phase, repeating the same analysis 3–6 months later. Disease activity was assessed by Juvenile Arthritis Disease Activity Score (JADAS) in AIJ; and by VASp, VASph and CRP in autoinflammatory diseases. Results: The sample included 90 patients (25 males) between the ages of 1 and 21 years (median 11.1); 61 diagnosed with JIA (excluding systemic category), and 29 with different autoinflammatory diseases (including systemic JIA). 69 patients (20 males, with median age 11.2, 48 AIJ, 21 autoinflammatory) participated in the prospective phase. The main results are shown in table 1. MRP=myeloid related proteins. JADAS=Juvenile arthritis disease activity score. ACJ=active joints count. VASm=visual analogue scale–physician. VASp=visual analogue scale-parents/patient. CRP=C reactive Protein. Conclusions: In patients with non-systemic JIA, a positive correlation was found between serum MRP8/14 and JADAS, VASph, VASp, CRP, WBC, neutrophilia and (inversely) haemoglobin. In autoinflammatory diseases positive correlation has been found with VASm, CRP, leukocytosis, neutrophilia, thrombocytosis and (inversely) haemoglobin. MRP8/14 seems to behave as a marker of activity in both JIA and autoinflammatory diseases, although with a stronger association in the latter. Disclosure of Interest: None declared