ConCeptCNN: A novel multi‐filter convolutional neural network for the prediction of neurodevelopmental disorders using brain connectome. Issue 5 (14th March 2022)

• Record Type: Journal Article
• Authors: Chen, Ming; Li, Hailong; Fan, Howard; Dillman, Jonathan R.; Wang, Hui; Altaye, Mekibib; Zhang, Bin; Parikh, Nehal A.; He, Lili
• Is Part Of: Medical physics. Volume 49:Issue 5(2022)
• Page Start: 3171
• Page End: 3184
• Publication Date: 2022-03-14
• Subjects: brain connectome -- convolutional neural network -- deep learning -- medical image analysis -- MRI; Medical physics -- Periodicals; Medical physics; Geneeskunde; Natuurkunde; Toepassingen; Biophysics; Periodicals; Periodicals; Electronic journals; 610.153
• DOI: 10.1002/mp.15545
• Languages: English
• ISSNs: 0094-2405

Abstract

Abstract: Background: Deep convolutional neural network (CNN) and its derivatives have recently shown great promise in the prediction of brain disorders using brain connectome data. Existing deep CNN methods using single global row and column convolutional filters have limited ability to extract discriminative information from brain connectome for prediction tasks. Purpose: This paper presents a novel deep Connectome–Inception CNN (ConCeptCNN) model, which is developed based on multiple convolutional filters. The proposed model is used to extract topological features from brain connectome data for neurological disorders classification and analysis. Methods: The ConCeptCNN uses multiple vector‐shaped filters extract topological information from the brain connectome at different levels for complementary feature embeddings of brain connectome. The proposed model is validated using two datasets: the Neuro Bureau ADHD‐200 dataset and the Cincinnati Early Prediction Study (CINEPS) dataset. Results: In a cross‐validation experiment, the ConCeptCNN achieved a prediction accuracy of 78.7% for the detection of attention deficit hyperactivity disorder (ADHD) in adolescents and an accuracy of 81.6% for the prediction of cognitive deficits at 2 years corrected age in very preterm infants. In addition to the classification tasks, the ConCeptCNN identified several brain regions that are discriminative to neurodevelopmental disorders. Conclusions: We compared the ConCeptCNN with several peer CNN methods. The results demonstrated that proposed model improves overall classification performance of neurodevelopmental disorders prediction tasks.