The CBI‐R detects early behavioural impairment in genetic frontotemporal dementia. Issue 5 (26th March 2022)

• Record Type: Journal Article
• Authors: Nelson, Annabel; Russell, Lucy L.; Peakman, Georgia; Convery, Rhian S.; Bouzigues, Arabella; Greaves, Caroline V.; Bocchetta, Martina; Cash, David M.; van Swieten, John C.; Jiskoot, Lize; Moreno, Fermin; Sanchez‐Valle, Raquel; Laforce, Robert; Graff, Caroline; Masellis, Mario; Tartaglia, Maria Carmela; Rowe, James B.; Borroni, Barbara; Finger, Elizabeth; Synofzik, Matthis; Galimberti, Daniela; Vandenberghe, Rik; de Mendonça, Alexandre; Butler, Chris R.; Gerhard, Alexander; Ducharme, Simon; Le Ber, Isabelle; Santana, Isabel; Pasquier, Florence; Levin, Johannes; Otto, Markus; Sorbi, Sandro; Rohrer, Jonathan D.;
• Other Names: Afonso Sónia investigator.; Almeida Maria Rosario investigator.; Anderl‐Straub Sarah investigator.; Andersson Christin investigator.; Antonell Anna investigator.; Archetti Silvana investigator.; Arighi Andrea investigator.; Balasa Mircea investigator.; Barandiaran Myriam investigator.; Bargalló Nuria investigator.; Bartha Robart investigator.; Bender Benjamin investigator.; Benussi Alberto investigator.; Bertoux Maxime investigator.; Bertrand Anne investigator.; Bessi Valentina investigator.; Black Sandra investigator.; Bocchetta Martina investigator.; Borrego‐Ecija Sergi investigator.; Bras Jose investigator.; Brice Alexis investigator.; Bruffaerts Rose investigator.; Camuzat Agnès investigator.; Cañada Marta investigator.; Cantoni Valentina investigator.; Caroppo Paola investigator.; Cash David investigator.; Castelo‐Branco Miguel investigator.; Colliot Olivier investigator.; Cope Thomas investigator.; Deramecourt Vincent investigator.; de Arriba María investigator.; Di Fede Giuseppe investigator.; Díez Alina investigator.; Duro Diana investigator.; Fenoglio Chiara investigator.; Ferrari Camilla investigator.; Ferreira Catarina B. investigator.; Fox Nick investigator.; Freedman Morris investigator.; Fumagalli Giorgio investigator.; Funkiewiez Aurélie investigator.; Gabilondo Alazne investigator.; Gasparotti Roberto investigator.; Gauthier Serge investigator.; Gazzina Stefano investigator.; Giaccone Giorgio investigator.; Gorostidi Ana investigator.; Greaves Caroline investigator.; Guerreiro Rita investigator.; Heller Carolin investigator.; Hoegen Tobias investigator.; Indakoetxea Begoña investigator.; Jelic Vesna investigator.; Karnath Hans‐Otto investigator.; Keren Ron investigator.; Kuchcinski Gregory investigator.; Langheinrich Tobias investigator.; Lebouvier Thibaud investigator.; Leitão Maria João investigator.; Lladó Albert investigator.; Lombardi Gemma investigator.; Loosli Sandra investigator.; Maruta Carolina investigator.; Mead Simon investigator.; Meeter Lieke investigator.; Miltenberger Gabriel investigator.; van Minkelen Rick investigator.; Mitchell Sara investigator.; Moore Katrina investigator.; Nacmias Benedetta investigator.; Nelson Annabel investigator.; Öijerstedt Linn investigator.; Olives Jaume investigator.; Ourselin Sebastien investigator.; Padovani Alessandro investigator.; Panman Jessica investigator.; Papma Janne M. investigator.; Pijnenburg Yolande investigator.; Polito Cristina investigator.; Premi Enrico investigator.; Prioni Sara investigator.; Prix Catharina investigator.; Rademakers Rosa investigator.; Redaelli Veronica investigator.; Rinaldi Daisy investigator.; Rittman Tim investigator.; Rogaeva Ekaterina investigator.; Rollin Adeline investigator.; Rosa‐Neto Pedro investigator.; Rossi Giacomina investigator.; Rossor Martin investigator.; Santiago Beatriz investigator.; Saracino Dario investigator.; Sayah Sabrina investigator.; Scarpini Elio investigator.; Schönecker Sonja investigator.; Seelaar Harro investigator.; Semler Elisa investigator.; Shafei Rachelle investigator.; Shoesmith Christen investigator.; Swift Imogen investigator.; Tábuas‐Pereira Miguel investigator.; Tainta Mikel investigator.; Taipa Ricardo investigator.; Tang‐Wai David investigator.; Thomas David L. investigator.; Thompson Paul investigator.; Thonberg Hakan investigator.; Timberlake Carolyn investigator.; Tiraboschi Pietro investigator.; Todd Emily investigator.; Van Damme Philip investigator.; Vandenbulcke Mathieu investigator.; Veldsman Michele investigator.; Verdelho Ana investigator.; Villanua Jorge investigator.; Warren Jason investigator.; Wilke Carlo investigator.; Wlasich Elisabeth investigator.; Zetterberg Henrik investigator.; Zulaica Miren investigator.;
• Is Part Of: Annals of clinical and translational neurology. Volume 9:Issue 5(2022)
• Page Start: 644
• Page End: 658
• Publication Date: 2022-03-26
• Subjects: Nervous system -- Diseases -- Periodicals; Neurology -- Periodicals; 616.8005
• DOI: 10.1002/acn3.51544
• Languages: English
• ISSNs: 2328-9503

Abstract

Abstract: Introduction: Behavioural dysfunction is a key feature of genetic frontotemporal dementia (FTD) but validated clinical scales measuring behaviour are lacking at present. Methods: We assessed behaviour using the revised version of the Cambridge Behavioural Inventory (CBI‐R) in 733 participants from the Genetic FTD Initiative study: 466 mutation carriers (195 C9orf72, 76 MAPT, 195 GRN ) and 267 non‐mutation carriers (controls). All mutation carriers were stratified according to their global CDR plus NACC FTLD score into three groups: asymptomatic (CDR = 0), prodromal (CDR = 0.5) and symptomatic (CDR = 1+). Mixed‐effects models adjusted for age, education, sex and family clustering were used to compare between the groups. Neuroanatomical correlates of the individual domains were assessed within each genetic group. Results: CBI‐R total scores were significantly higher in all CDR 1+ mutation carrier groups compared with controls [ C9orf72 mean 70.5 (standard deviation 27.8), GRN 56.2 (33.5), MAPT 62.1 (36.9)] as well as their respective CDR 0.5 groups [ C9orf72 13.5 (14.4), GRN 13.3 (13.5), MAPT 9.4 (10.4)] and CDR 0 groups [ C9orf72 6.0 (7.9), GRN 3.6 (6.0), MAPT 8.5 (13.3)]. The C9orf72 and GRN 0.5 groups scored significantly higher than the controls. The greatest impairment was seen in the Motivation domain for the C9orf72 and GRN symptomatic groups, whilst in the symptomatic MAPT group, the highest‐scoring domains were Stereotypic and Motor Behaviours and Memory and Orientation. Neural correlates of each CBI‐R domain largely overlapped across the different mutation carrier groups. Conclusions: The CBI‐R detects early behavioural change in genetic FTD, suggesting that it could be a useful measure within future clinical trials.