Dupilumab unmasking cutaneous T‐cell lymphoma: report of a fatal case. (9th February 2022)

• Record Type: Journal Article
• Authors: Poyner, Elizabeth F. M.; Bacon, Chris M.; Osborne, Wendy; Frew, John A.; Weatherhead, Sophie C.
• Is Part Of: Clinical and experimental dermatology. Volume 47:Number 5(2022)
• Page Start: 974
• Page End: 976
• Publication Date: 2022-02-09
• Subjects: Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/ced.15079
• Languages: English
• ISSNs: 0307-6938

Abstract

We present a 60‐year‐old man who was started on dupilumab for severe atopic dermatitis. After initial improvement his skin deteriorated and 'unmasked' cutaneous T cell lymphoma, which rapidly progressed resulting in his death 12 months after dupilumab was stopped. This case adds to the evidence that dupilumab can cause CTCL progression and highlights the importance of re‐evaluating patient diagnosis to exclude CTCL prior to starting this biologic: