A Gradient pH‐Sensitive Polymer‐Based Antiviral Strategy via Viroporin‐Induced Membrane Acidification (Adv. Mater. 18/2022). Issue 18 (5th May 2022)

• Record Type: Journal Article
• Authors: Sun, Yizhe; Gong, Lidong; Yin, Yue; Zhang, Lei; Sun, Qiangming; Feng, Kai; Cui, Yimin; Zhang, Qiang; Zhang, Xuehui; Deng, Xuliang; You, Fuping; Lu, Dan; Lin, Zhiqiang
• Is Part Of: Advanced materials. Volume 34:Issue 18(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-05
• Subjects: coronavirus -- pH‐sensitivity -- polymers -- viral envelopes -- viroporins; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202270135
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : Antiviral Strategies A gradient pH‐sensitive (GPS) polymer is developed by Fuping You, Dan Lu, Zhiqiang Lin, and co‐workers in article number 2109580 . In response to an acidified membrane, the GPS polymer with dye conjugation illuminates, targets, and lyses the envelope of viruses, resulting in leakage of viral nucleic acid and a broad‐spectrum activity of the GPS polymer against a variety of viruses.