Simultaneous pancreas‐kidney transplantation in Caucasian versus African American patients: Does recipient race influence outcomes?. Issue 5 (31st January 2022)

• Record Type: Journal Article
• Authors: Rogers, Jeffrey; Jay, Colleen L.; Farney, Alan C.; Orlando, Giuseppe; Jacobs, Marie L.; Harriman, David; Gurram, Venkat; Sharda, Berjesh; Gurung, Komal; Reeves‐Daniel, Amber; Doares, William; Kaczmorski, Scott; Mena‐Gutierrez, Alejandra; Sakhovskaya, Natalia; Gautreaux, Michael D.; Stratta, Robert J.
• Is Part Of: Clinical transplantation. Volume 36:Issue 5(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-01-31
• Subjects: African American -- alemtuzumab -- portal‐enteric drainage -- race -- simultaneous pancreas‐kidney transplant; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.14599
• Languages: English
• ISSNs: 0902-0063

Abstract

Abstract: The influence of African American (AA) recipient race on outcomes following simultaneous pancreas‐kidney transplantation (SPKT) is uncertain. Methods: From 11/01 to 2/19, we retrospectively studied 158 Caucasian (C) and 57 AA patients (pts) undergoing SPKT. Results: The AA group had fewer patients on peritoneal dialysis (30% C vs. 14% AA), more patients with longer dialysis duration (28% C vs. 51% AA), more sensitized (PRA ≥20%) patients (6% C vs. 21% AA), and more patients with pretransplant C‐peptide levels ≥2.0 ng/ml (11% C vs. 35% AA, all P < .05). With a mean 9.2 year follow‐up, patient survival (65% C vs. 77% AA, P = .098) slightly favored the AA group, whereas kidney (55% C vs. 60% AA) and pancreas (48% C vs. 54% AA) graft survival rates (GSRs) were comparable. Death‐censored kidney (71% C vs. 68% AA) and pancreas (both 62%) GSRs demonstrated that death with a functioning graft (DWFG) was more common in C vs. AA patients (23% C vs. 12% AA, P = .10). The incidence of death‐censored dual graft loss (usually rejection) was 7% C versus 21% AA ( P = .005). Conclusions: Following SPKT, AA patients are at a greater risk for dual immunological graft loss whereas C patients are at greater risk for DWFG.