Investigating the solubility and cytocompatibility of CaO–Na2O–SiO2/TiO2 bioactive glasses. Issue 2 (23rd May 2014)

• Record Type: Journal Article
• Authors: Wren, Anthony W.; Coughlan, Aisling; Smith, Courtney M.; Hudson, Sarah P.; Laffir, Fathima R.; Towler, Mark R.
• Is Part Of: Journal of biomedical materials research. Volume 103:Issue 2(2015:Feb.)
• Page Start: 709
• Page End: 720
• Publication Date: 2014-05-23
• Subjects: bioactive glass -- solubility -- particle size -- ion release -- cell culture; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.35223
• Languages: English
• ISSNs: 1549-3296

Abstract

Abstract: This study aims to investigate the solubility of a series of titanium (TiO2 )‐containing bioactive glasses and their subsequent effect on cell viability. Five glasses were synthesized in the composition range SiO2 –Na2 O–CaO with 5 mol % of increments TiO2 substituted for SiO2 . Glass solubility was investigated with respect to (1) exposed surface area, (2) particle size, (3) incubation time, and (4) compositional effects. Ion release profiles showed that sodium (Na + ) presented high release rates after 1 day and were unchanged between 7 and 14 days. Calcium (Ca 2+ ) release presented a significant change at each time period and was also composition dependent, where a reduction in Ca 2+ release is observed with an increase in TiO2 concentration. Silica (Si 4+ ) release did not present any clear trends while no titanium (Ti 4+ ) was released. Cell numbers were found to increase up to 44%, compared to the growing control population, with a reduction in particle size and with the inclusion of TiO2 in the glass composition. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 709–720, 2015.