Involvement of phase II enzymes and efflux transporters in the metabolism and absorption of naringin, hesperidin and their aglycones in rats. (19th May 2022)

• Record Type: Journal Article
• Authors: Guo, Xiao; Cao, Xuedan; Fang, Xiugui; Guo, Ailing; Li, Erhu
• Is Part Of: International journal of food sciences and nutrition. Volume 73:Number 4(2022)
• Page Start: 480
• Page End: 490
• Publication Date: 2022-05-19
• Subjects: Naringin -- hesperidin -- naringenin -- hesperetin -- bioavailability -- phase II metabolism -- efflux transportation; Food -- Analysis -- Periodicals; Nutrition -- Periodicals; 641.3
• DOI: 10.1080/09637486.2021.2012562
• Languages: English
• ISSNs: 0963-7486

Abstract

Abstract: This study examined the effects of phase II metabolism and efflux transportation on the bioavailability of naringin, hesperidin, and their aglycones (naringenin and hesperetin) in rats. Results indicated naringin and hesperidin have a lower oral bioavailability than their aglycones. Of all the phase II enzymes tested, UDP-glucuronosyltransferase (UGT) 1A1, UGT1A2, UGT1A3, UGT1A7 and SULT sulfotransferase (SULT) 1B1 were of minor importance regarding the phase II metabolism of naringenin and hesperetin in the small intestine. Naringin, hesperidin, and their aglycones were all extensively metabolised in the liver. Naringin and hesperidin were more extensively transported by efflux transporters compared to their aglycones. Significant correlations between phase II enzymes and efflux transporters were detected. In conclusion, more extensive metabolism of naringin and hesperidin than their aglycones in the small intestine, and the interplay of phase II enzymes and efflux transporters in the small intestine explain the lower relative oral bioavailability of naringin and hesperidin than their aglycones.