Carambola-like Bi2Te3 superstructures with enhanced photoabsorption for highly efficient photothermal therapy in the second near-infrared biowindow. Issue 35 (14th June 2021)

• Record Type: Journal Article
• Authors: Zhao, Ying; Liu, Yang; Wang, Qishun; Liu, Jianhua; Zhang, Songtao; Zhang, Tianqi; Wang, Daguang; Wang, Yinghui; Jin, Longhai; Zhang, Hongjie
• Is Part Of: Journal of materials chemistry. Volume 9:Issue 35(2021)
• Page Start: 7271
• Page End: 7277
• Publication Date: 2021-06-14
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d1tb00694k
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Carambola-like Bi2 Te3 superstructures endow Bi2 Te3 @PEG with enhanced photoabsorption in the near-infrared region, making them a promising tool for highly efficient photothermal therapy in the second near-infrared biowindow. Abstract : Photothermal therapy (PTT) stimulated by light in the second near-infrared (NIR-II) biowindow shows great superiorities in the penetration ability of tissue and maximum permissible exposure (MPE). Exploring new photothermal agents with good optical absorbance in the NIR-II region is highly desirable for efficient cancer therapy. Herein, we successfully prepare carambola-like bismuth telluride (Bi2 Te3 ) superstructures modified with PEGylated phospholipid (Bi2 Te3 @PEG) for CT imaging-guided PTT in the NIR-II biowindow. Attributing to their superstructures, Bi2 Te3 @PEG exhibited enhanced photoabsorption with higher photothermal conversion efficiency (55.3% for 1064 nm) compared with that of Bi2 Te3 nanoparticles. Furthermore, the good X-ray attenuation capacity of Bi endows Bi2 Te3 @PEG with an outstanding performance as computed tomography (CT) contrast agents. Bi2 Te3 @PEG superstructures have been confirmed to effectively eliminate tumor in vitro and in vivo with negligible long-term toxicities, offering them great potential to act as theranostic platforms for cancer diagnosis and treatment.